Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7E14

Compound2_GLP-1R_OWL833_Gs complex structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B	0007265	biological_process	Ras protein signal transduction
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0070062	cellular_component	extracellular exosome
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
B	1903561	cellular_component	extracellular vesicle
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0048144	biological_process	fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004967	molecular_function	glucagon receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0007190	biological_process	activation of adenylate cyclase activity
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0007611	biological_process	learning or memory
R	0008016	biological_process	regulation of heart contraction
R	0016020	cellular_component	membrane
R	0017046	molecular_function	peptide hormone binding
R	0019933	biological_process	cAMP-mediated signaling
R	0031204	biological_process	post-translational protein targeting to membrane, translocation
R	0038023	molecular_function	signaling receptor activity
R	0044508	molecular_function	glucagon-like peptide 1 receptor activity
R	0045776	biological_process	negative regulation of blood pressure
R	0045777	biological_process	positive regulation of blood pressure
R	0046879	biological_process	hormone secretion
R	0071377	biological_process	cellular response to glucagon stimulus
R	1990911	biological_process	response to psychosocial stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue V6G R 501

Chain	Residue
R	SER31
R	ASP198
R	LYS202
R	MET204
R	TYR205
R	TYR220
R	CYS226
R	VAL229
R	PHE230
R	MET233
R	THR298
R	GLU34
R	PRO137
R	GLU138
R	LEU141
R	LEU144
R	TYR145
R	TYR148
R	LYS197

site_id	AC2
Number of Residues	5
Details	binding site for residue CLR R 502

Chain	Residue
R	TYR235
R	ARG267
R	TRP274
R	LEU278
R	CLR503

site_id	AC3
Number of Residues	5
Details	binding site for residue CLR R 503

Chain	Residue
R	LEU189
R	PHE266
R	TRP274
R	CLR502
R	CLR506

site_id	AC4
Number of Residues	2
Details	binding site for residue CLR R 504

Chain	Residue
R	ALA350
R	CLR505

site_id	AC5
Number of Residues	5
Details	binding site for residue CLR R 505

Chain	Residue
R	ILE328
R	CYS329
R	VAL332
R	THR362
R	CLR504

site_id	AC6
Number of Residues	2
Details	binding site for residue CLR R 506

Chain	Residue
R	LEU181
R	CLR503

site_id	AC7
Number of Residues	1
Details	binding site for residue HNO R 507

Chain	Residue
R	CYS347

Functional Information from PROSITE/UniProt

site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP

Chain	Residue	Details
R	CYS62-PRO86

site_id	PS00650
Number of Residues	16
Details	G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV

Chain	Residue	Details
R	GLN394-VAL409

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
G	ALA2
A	SER192
A	PHE345
A	SER352
A	ASN371

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Cysteine methyl ester => ECO:0000250\|UniProtKB:P63212

Chain	Residue	Details
G	CYS68

site_id	SWS_FT_FI3
Number of Residues	1
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250\|UniProtKB:P63212

Chain	Residue	Details
G	CYS68
R	TYR252-ILE265
R	CYS329-ARG348
R	VAL405-SER463

site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: N-palmitoyl glycine => ECO:0000250\|UniProtKB:P04896

Chain	Residue	Details
A	GLY2

site_id	SWS_FT_FI5
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:21044946

Chain	Residue	Details
A	CYS3

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
R	PHE266-LEU290

site_id	SWS_FT_FI7
Number of Residues	22
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
R	TRP306-ILE328

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
R	LEU349-VAL370

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
R	LEU384-PHE404

site_id	SWS_FT_FI10
Number of Residues	2
Details	SITE: Interaction with the endogenous ligand GLP-1 => ECO:0000269\|PubMed:19861722

Chain	Residue	Details
R	ARG121
R	GLU128

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: ADP-ribosylcysteine => ECO:0000269\|PubMed:21901419

Chain	Residue	Details
R	CYS341

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: ADP-ribosylarginine => ECO:0000269\|PubMed:21901419

Chain	Residue	Details
R	ARG348

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:22412906

Chain	Residue	Details
R	ASN63
R	ASN82
R	ASN115

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)