7A17
Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Synaptojanin-1 | polymer | 346 | 39607.1 | 1 | UniProt (O43426) Pfam (PF22669) | Homo sapiens (Human) | Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 |
| 2 | B (B) | Nanobody 13015 | polymer | 119 | 13031.3 | 1 | Lama glama | ||
| 3 | C, E (C, E) | Isoform 2 of Synaptojanin-1 | polymer | 345 | 39520.0 | 2 | UniProt (O43426) Pfam (PF22669) | Homo sapiens (Human) | Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 |
| 4 | D (D) | Nanobody 13015 | polymer | 123 | 13442.7 | 1 | Lama glama | ||
| 5 | F (F) | Nanobody 13015 | polymer | 125 | 13719.0 | 1 | Lama glama | ||
| 6 | G (A) | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate | non-polymer | 826.5 | 1 | Chemie (IP9) | |||
| 7 | H, N (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 8 | I, J (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | K, L, M, O (C, E) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 10 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158840.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1439.2 | |
| All* | Total formula weight | 160279.3 |
