6YAF
AP2 on a membrane containing tyrosine-based cargo peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AP-2 complex subunit alpha-2 | polymer | 628 | 70310.1 | 1 | UniProt (P18484) Pfam (PF01602) | Rattus norvegicus (Norway rat) | 100 kDa coated vesicle protein C,Adaptor protein complex AP-2 subunit alpha-2,Adaptor-related protein complex 2 subunit alpha-2,Alpha-adaptin C,Alpha2-adaptin,Clathrin assembly protein complex 2 alpha-C large chain,Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit |
| 2 | B (B) | AP-2 complex subunit beta | polymer | 944 | 105619.3 | 1 | UniProt (P63010) Pfam (PF01602) Pfam (PF02883) Pfam (PF09066) | Homo sapiens (Human) | AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit |
| 3 | C (M) | AP-2 complex subunit mu | polymer | 446 | 51044.1 | 1 | UniProt (P84092) Pfam (PF01217) Pfam (PF00928) | Rattus norvegicus (Norway rat) | AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein |
| 4 | D (P) | Tyrosine type cargo signal derived from TGN38 | polymer | 16 | 1940.3 | 1 | UniProt (by SIFTS) (O43493) | Homo sapiens | |
| 5 | E (S) | AP-2 complex subunit sigma | polymer | 142 | 17038.7 | 1 | UniProt (P62743) Pfam (PF01217) | Mus musculus (House mouse) | Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin |
Sequence modifications
A: 1 - 623 (UniProt: P18484)
B: 1 - 937 (UniProt: P63010)
M: 1 - 446 (UniProt: P84092)
| PDB | External Database | Details |
|---|---|---|
| Asp 8 | Glu 8 | conflict |
| Glu 272 | - | insertion |
| Gly 622 | Pro 621 | conflict |
| Gly 624 | - | expression tag |
| Leu 625 | - | expression tag |
| Val 626 | - | expression tag |
| Pro 627 | - | expression tag |
| Arg 628 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 237 | - | insertion |
| Glu 238 | - | insertion |
| Gln 239 | - | insertion |
| Lys 240 | - | insertion |
| Leu 241 | - | insertion |
| Ile 242 | - | insertion |
| Ser 243 | - | insertion |
| Glu 244 | - | insertion |
| Glu 245 | - | insertion |
| Asp 246 | - | insertion |
| Leu 247 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 245952.5 | |
| All* | Total formula weight | 245952.5 |
