6YAF

AP2 on a membrane containing tyrosine-based cargo peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0005048	molecular_function	signal sequence binding
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005905	cellular_component	clathrin-coated pit
B	0006886	biological_process	intracellular protein transport
B	0006897	biological_process	endocytosis
B	0007268	biological_process	chemical synaptic transmission
B	0007269	biological_process	neurotransmitter secretion
B	0008021	cellular_component	synaptic vesicle
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0012505	cellular_component	endomembrane system
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030118	cellular_component	clathrin coat
B	0030122	cellular_component	AP-2 adaptor complex
B	0030131	cellular_component	clathrin adaptor complex
B	0030276	molecular_function	clathrin binding
B	0030666	cellular_component	endocytic vesicle membrane
B	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0035615	molecular_function	clathrin adaptor activity
B	0036020	cellular_component	endolysosome membrane
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0045334	cellular_component	clathrin-coated endocytic vesicle
B	0045807	biological_process	positive regulation of endocytosis
B	0048268	biological_process	clathrin coat assembly
B	0048488	biological_process	synaptic vesicle endocytosis
B	0072583	biological_process	clathrin-dependent endocytosis
B	0098843	cellular_component	postsynaptic endocytic zone
B	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
B	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
B	0098978	cellular_component	glutamatergic synapse
B	1905477	biological_process	positive regulation of protein localization to membrane
M	0006886	biological_process	intracellular protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030131	cellular_component	clathrin adaptor complex
S	0005515	molecular_function	protein binding
S	0005886	cellular_component	plasma membrane
S	0005905	cellular_component	clathrin-coated pit
S	0006886	biological_process	intracellular protein transport
S	0006897	biological_process	endocytosis
S	0008021	cellular_component	synaptic vesicle
S	0009898	cellular_component	cytoplasmic side of plasma membrane
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030122	cellular_component	AP-2 adaptor complex
S	0035615	molecular_function	clathrin adaptor activity
S	0045202	cellular_component	synapse
S	0048488	biological_process	synaptic vesicle endocytosis
S	0072583	biological_process	clathrin-dependent endocytosis
S	0098794	cellular_component	postsynapse
S	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
S	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
S	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF

Chain	Residue	Details
S	ILE57-PHE67

---

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
M	ILE159-GLU179

---

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
M	ILE274-TYR288

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12086608","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25061211","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UQI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q96CW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q96CW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Motif: {"description":"Endocytosis signal; in isoform TGN46 and isoform TGN48"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P53680","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---