6U1N
GPCR-Beta arrestin structure in lipid bilayer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Muscarinic acetylcholine receptor M2, Vasopressin V2 receptor chimera | polymer | 509 | 56616.2 | 1 | UniProt (P08172) UniProt (P30518) Pfam (PF00001) In PDB | Homo sapiens (Human) | V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor |
2 | C | Beta-arrestin-1 | polymer | 401 | 45017.2 | 1 | UniProt (P29066) Pfam (PF00339) Pfam (PF02752) In PDB | Rattus norvegicus (Rat) | Arrestin beta-1 |
3 | H | Fab30 heavy chain | polymer | 237 | 25512.4 | 1 | UniProt (V9HW68) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
4 | L | Fab30 light chain | polymer | 215 | 23435.1 | 1 | UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
5 | R | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide | non-polymer | 437.9 | 1 | Chemie (2CU) |
Sequence modifications
R: 2 - 466 (UniProt: P08172)
R: 474 - 502 (UniProt: P30518)
C: 2 - 393 (UniProt: P29066)
H: 1 - 112 (PDB: 6U1N)
H: 113 - 230 (UniProt: V9HW68)
L: 1 - 105 (PDB: 6U1N)
L: 106 - 215 (UniProt: Q7Z3Y4)
PDB | External Database | Details |
---|---|---|
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
Leu 467 | - | linker |
Pro 468 | - | linker |
Glu 469 | - | linker |
Thr 470 | - | linker |
Gly 471 | - | linker |
Gly 472 | - | linker |
Gly 473 | - | linker |
C: 2 - 393 (UniProt: P29066)
PDB | External Database | Details |
---|---|---|
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Pro -5 | - | expression tag |
Glu -4 | - | expression tag |
Phe -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Leu 1 | - | expression tag |
Val 59 | Cys 59 | engineered mutation |
Ser 125 | Cys 125 | engineered mutation |
Leu 140 | Cys 140 | engineered mutation |
Val 150 | Cys 150 | engineered mutation |
Val 242 | Cys 242 | engineered mutation |
Val 251 | Cys 251 | engineered mutation |
Ser 269 | Cys 269 | engineered mutation |
H: 113 - 230 (UniProt: V9HW68)
PDB | External Database | Details |
---|---|---|
His 231 | - | expression tag |
His 232 | - | expression tag |
His 233 | - | expression tag |
His 234 | - | expression tag |
His 235 | - | expression tag |
His 236 | - | expression tag |
His 237 | - | expression tag |
L: 106 - 215 (UniProt: Q7Z3Y4)
PDB | External Database | Details |
---|---|---|
Ser 124 | Glu 145 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 150580.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 437.9 | |
All* | Total formula weight | 151018.7 |