Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6U1N

GPCR-Beta arrestin structure in lipid bilayer

Functional Information from GO Data
ChainGOidnamespacecontents
C0000785cellular_componentchromatin
C0001664molecular_functionG protein-coupled receptor binding
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0002031biological_processG protein-coupled receptor internalization
C0002092biological_processpositive regulation of receptor internalization
C0003713molecular_functiontranscription coactivator activity
C0004402molecular_functionhistone acetyltransferase activity
C0005096molecular_functionGTPase activator activity
C0005102molecular_functionsignaling receptor binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005905cellular_componentclathrin-coated pit
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006511biological_processubiquitin-dependent protein catabolic process
C0006897biological_processendocytosis
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007601biological_processvisual perception
C0007602biological_processphototransduction
C0008277biological_processregulation of G protein-coupled receptor signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009968biological_processnegative regulation of signal transduction
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016323cellular_componentbasolateral plasma membrane
C0016567biological_processprotein ubiquitination
C0019899molecular_functionenzyme binding
C0030276molecular_functionclathrin binding
C0030331molecular_functionnuclear estrogen receptor binding
C0031143cellular_componentpseudopodium
C0031397biological_processnegative regulation of protein ubiquitination
C0031398biological_processpositive regulation of protein ubiquitination
C0031410cellular_componentcytoplasmic vesicle
C0031434molecular_functionmitogen-activated protein kinase kinase binding
C0031625molecular_functionubiquitin protein ligase binding
C0031691molecular_functionalpha-1A adrenergic receptor binding
C0031692molecular_functionalpha-1B adrenergic receptor binding
C0031701molecular_functionangiotensin receptor binding
C0031762molecular_functionfollicle-stimulating hormone receptor binding
C0031896molecular_functionV2 vasopressin receptor binding
C0032715biological_processnegative regulation of interleukin-6 production
C0032717biological_processnegative regulation of interleukin-8 production
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034393biological_processpositive regulation of smooth muscle cell apoptotic process
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035612molecular_functionAP-2 adaptor complex binding
C0035615molecular_functionclathrin adaptor activity
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042699biological_processfollicle-stimulating hormone signaling pathway
C0042981biological_processregulation of apoptotic process
C0042995cellular_componentcell projection
C0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043197cellular_componentdendritic spine
C0043278biological_processresponse to morphine
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0044325molecular_functiontransmembrane transporter binding
C0045211cellular_componentpostsynaptic membrane
C0045309molecular_functionprotein phosphorylated amino acid binding
C0045746biological_processnegative regulation of Notch signaling pathway
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050975biological_processsensory perception of touch
C0051219molecular_functionphosphoprotein binding
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0098978cellular_componentglutamatergic synapse
C1990763molecular_functionarrestin family protein binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0006955biological_processimmune response
R0004930molecular_functionG protein-coupled receptor activity
R0004993molecular_functionG protein-coupled serotonin receptor activity
R0005886cellular_componentplasma membrane
R0006940biological_processregulation of smooth muscle contraction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007197biological_processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
R0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
R0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
R0007268biological_processchemical synaptic transmission
R0007399biological_processnervous system development
R0008016biological_processregulation of heart contraction
R0009615biological_processresponse to virus
R0016020cellular_componentmembrane
R0016907molecular_functionG protein-coupled acetylcholine receptor activity
R0030425cellular_componentdendrite
R0030669cellular_componentclathrin-coated endocytic vesicle membrane
R0032279cellular_componentasymmetric synapse
R0032280cellular_componentsymmetric synapse
R0042734cellular_componentpresynaptic membrane
R0043025cellular_componentneuronal cell body
R0043679cellular_componentaxon terminus
R0045202cellular_componentsynapse
R0045211cellular_componentpostsynaptic membrane
R0095500biological_processacetylcholine receptor signaling pathway
R0098664biological_processG protein-coupled serotonin receptor signaling pathway
R0098978cellular_componentglutamatergic synapse
R0098981cellular_componentcholinergic synapse
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R1990763molecular_functionarrestin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 2CU R 601
ChainResidue
RTYR83
RASN419
RTRP422
RGLY87
RCYS176
RTYR177
RILE178
RPHE181
RASN410
RALA414
RPRO415

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR204-HIS210
LTYR193-HIS199

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVmNLLIISFDRYFcV
ChainResidueDetails
RALA109-VAL125

site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
CPHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CLYS250
CMET255
CLYS324
CLYS326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8
ChainResidueDetails
RASP120-MET139
RSER210-ARG387
RCYS443-ARG466
CTYR47

site_idSWS_FT_FI3
Number of Residues20
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
RTYR60-TYR80

site_idSWS_FT_FI4
Number of Residues44
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
RTHR81-ASP97
RGLN163-ALA184
RTHR411-PRO418

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
RLEU98-PHE119

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
RALA140-TRP162

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
RALA185-ILE209

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
RTHR388-ASN410

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
RASN419-LEU442

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ERZ4
ChainResidueDetails
RSER232

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0000255
ChainResidueDetails
RTHR446
RTHR450
RTHR465

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN2
RASN3
RASN6
RASN9

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon