6QIP

Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the albumin-biniding side chain of the human growth hormone derivative somapacitan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serum albumin	polymer	585	66473.1	1	UniProt (P02768) Pfam (PF00273)	Homo sapiens (human)
2	B (B)	IgG receptor FcRn large subunit p51	polymer	274	30408.1	1	UniProt (P55899) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor
3	C (C)	Beta-2-microglobulin	polymer	105	12577.0	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
4	D (A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
5	E (A)	Somapacitan	non-polymer		1192.4	1	Chemie (JG5)
6	F (A)	BETA-MERCAPTOETHANOL	non-polymer		78.1	1	Chemie (BME)
7	G (B)	CYSTEINE	non-polymer		121.2	1	Chemie (CYS)
8	H, I, J (A, B, C)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 1 - 585 (UniProt: P02768)

PDB	External Database	Details
Met 418	Val 442	engineered mutation
Ala 420	Thr 444	engineered mutation
Gly 505	Glu 529	engineered mutation
Ala 547	Val 571	engineered mutation

C: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
His 100	-	expression tag
His 101	-	expression tag
His 102	-	expression tag
His 103	-	expression tag
His 104	-	expression tag
His 105	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	109458.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1586.9
All*	Total formula weight	111045.2

*Water molecules are not included.