6PW3
LARP1 DM15 FYRE (F844Y, R847E) mutant bound to m7GpppG dinucleotide (capG)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, A, B, D) | La-related protein 1 | polymer | 162 | 19604.2 | 4 | UniProt (Q6PKG0) Pfam (PF21071) | Homo sapiens (Human) | La ribonucleoprotein domain family member 1 |
| 2 | E, G (C, B) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE | non-polymer | 803.4 | 2 | Chemie (GTG) | |||
| 3 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | H, I, J, K (C, A, B, D) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
C, A, B, D: 796 - 946 (UniProt: Q6PKG0)
| PDB | External Database | Details |
|---|---|---|
| Gly 785 | - | expression tag |
| His 786 | - | expression tag |
| Ser 787 | - | expression tag |
| Gly 788 | - | expression tag |
| Gly 789 | - | expression tag |
| Gly 790 | - | expression tag |
| Gly 791 | - | expression tag |
| Gly 792 | - | expression tag |
| Gly 793 | - | expression tag |
| His 794 | - | expression tag |
| Met 795 | - | expression tag |
| Tyr 844 | Phe 844 | engineered mutation |
| Glu 847 | Arg 847 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 78416.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1631.2 | |
| All* | Total formula weight | 80048.0 |
