6PW3

LARP1 DM15 FYRE (F844Y, R847E) mutant bound to m7GpppG dinucleotide (capG)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000339	molecular_function	RNA cap binding
A	0048255	biological_process	mRNA stabilization
B	0000339	molecular_function	RNA cap binding
B	0048255	biological_process	mRNA stabilization
C	0000339	molecular_function	RNA cap binding
C	0048255	biological_process	mRNA stabilization
D	0000339	molecular_function	RNA cap binding
D	0048255	biological_process	mRNA stabilization

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GTG C 1001

Chain	Residue
C	SER843
C	LYS915
C	ALA918
C	TYR922
C	TYR844
C	GLU847
C	ARG879
C	SER882
C	TYR883
C	GLU886
C	TYR911
C	GLU914

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 1001

Chain	Residue
A	ARG871
A	GLU875
A	TYR911
B	GLU875

---

site_id	AC3
Number of Residues	17
Details	binding site for residue GTG B 1001

Chain	Residue
A	SER843
A	TYR844
A	GLU847
A	ARG879
A	TYR883
A	TYR911
A	GLU914
A	LYS915
B	SER843
B	TYR844
B	GLU847
B	ARG879
B	TYR883
B	TYR911
B	GLU914
B	LYS915
C	LYS815

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	Region: {"description":"Interaction with 7-methylguanosine mRNA cap structure","evidences":[{"source":"PubMed","id":"28379136","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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