6O60

Crystal structure of GGTase3-FBXL2-SKP1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein prenyltransferase alpha subunit repeat-containing protein 1	polymer	407	46813.3	1	UniProt (Q7Z6K3) Pfam (PF01239)	Homo sapiens (Human)
2	B (B)	Geranylgeranyl transferase type-2 subunit beta	polymer	332	37047.4	1	UniProt (P53611) Pfam (PF00432)	Homo sapiens (Human)	Geranylgeranyl transferase type II subunit beta,GGTase-II-beta,Rab geranyl-geranyltransferase subunit beta,Rab GGTase beta,Rab geranylgeranyltransferase subunit beta,Type II protein geranyl-geranyltransferase subunit beta
3	C (C)	F-box/LRR-repeat protein 2	polymer	424	47208.7	1	UniProt (Q9UKC9) Pfam (PF00646) Pfam (PF25372)	Homo sapiens (Human)	F-box and leucine-rich repeat protein 2,F-box protein FBL2/FBL3
4	D (D)	S-phase kinase-associated protein 1	polymer	164	18767.0	1	UniProt (P63208) Pfam (PF01466) Pfam (PF03931)	Homo sapiens (Human)	Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1
5	E (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	F, G, H, I (A, B, C, D)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 1 - 402 (UniProt: Q7Z6K3)

PDB	External Database	Details
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag

B: 1 - 331 (UniProt: P53611)

PDB	External Database	Details
Ser 0	-	expression tag

C: 1 - 423 (UniProt: Q9UKC9)

PDB	External Database	Details
Ser 0	-	expression tag

D: 1 - 163 (UniProt: P63208)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149836.4
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	149901.8

*Water molecules are not included.