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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6O60

Crystal structure of GGTase3-FBXL2-SKP1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004663molecular_functionRab geranylgeranyltransferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0008318molecular_functionprotein prenyltransferase activity
A0018342biological_processprotein prenylation
B0003824molecular_functioncatalytic activity
B0004659molecular_functionprenyltransferase activity
B0004661molecular_functionprotein geranylgeranyltransferase activity
B0004663molecular_functionRab geranylgeranyltransferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005968cellular_componentRab-protein geranylgeranyltransferase complex
B0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
B0007601biological_processvisual perception
B0008270molecular_functionzinc ion binding
B0008318molecular_functionprotein prenyltransferase activity
B0016740molecular_functiontransferase activity
B0018344biological_processprotein geranylgeranylation
B0031267molecular_functionsmall GTPase binding
B0036211biological_processprotein modification process
B0046872molecular_functionmetal ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0010506biological_processregulation of autophagy
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0019005cellular_componentSCF ubiquitin ligase complex
C0019903molecular_functionprotein phosphatase binding
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0031347biological_processregulation of defense response
C0036211biological_processprotein modification process
C0036312molecular_functionphosphatidylinositol 3-kinase regulatory subunit binding
C0044830biological_processhost-mediated perturbation of viral RNA genome replication
C0050727biological_processregulation of inflammatory response
C0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
C1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D0000082biological_processG1/S transition of mitotic cell cycle
D0000209biological_processprotein polyubiquitination
D0000785cellular_componentchromatin
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006511biological_processubiquitin-dependent protein catabolic process
D0006879biological_processintracellular iron ion homeostasis
D0007346biological_processregulation of mitotic cell cycle
D0008013molecular_functionbeta-catenin binding
D0010564biological_processregulation of cell cycle process
D0010824biological_processregulation of centrosome duplication
D0014033biological_processneural crest cell differentiation
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0030510biological_processregulation of BMP signaling pathway
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031507biological_processheterochromatin formation
D0031519cellular_componentPcG protein complex
D0032006biological_processregulation of TOR signaling
D0042752biological_processregulation of circadian rhythm
D0042981biological_processregulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0050727biological_processregulation of inflammatory response
D0051124biological_processsynaptic assembly at neuromuscular junction
D0051298biological_processcentrosome duplication
D0051457biological_processmaintenance of protein location in nucleus
D0051726biological_processregulation of cell cycle
D0060173biological_processlimb development
D0060271biological_processcilium assembly
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1901524biological_processregulation of mitophagy
D1904415biological_processregulation of xenophagy
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D1990757molecular_functionubiquitin ligase activator activity
D2000001biological_processregulation of DNA damage checkpoint
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN B 401
ChainResidue
BASP238
BCYS240
BHIS290
DASP38
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues34
DetailsRepeat: {"description":"PFTA 1","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsRepeat: {"description":"PFTA 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues39
DetailsRepeat: {"description":"PFTA 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues39
DetailsRepeat: {"description":"PFTA 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsRepeat: {"description":"PFTA 5","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues34
DetailsRepeat: {"description":"PFTA 6","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues47
DetailsRepeat: {"description":"PFTB 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues46
DetailsRepeat: {"description":"PFTB 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues48
DetailsRepeat: {"description":"PFTB 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues47
DetailsRepeat: {"description":"PFTB 5","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues48
DetailsRepeat: {"description":"PFTB 6","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q08603","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32128853","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues46
DetailsDomain: {"description":"F-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00080","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues25
DetailsRepeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues25
DetailsRepeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues25
DetailsRepeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues25
DetailsRepeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues25
DetailsRepeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues25
DetailsRepeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues25
DetailsRepeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues25
DetailsRepeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues25
DetailsRepeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues28
DetailsRepeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues24
DetailsRepeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"31209342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O60","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues10
DetailsRegion: {"description":"Interaction with Calmodulin","evidences":[{"source":"UniProtKB","id":"Q8BH16","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8BH16","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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