6LI0
Crystal structure of GPR52 in complex with agonist c17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chimera of G-protein coupled receptor 52 and Flavodoxin | polymer | 468 | 52603.4 | 1 | UniProt (Q9Y2T5) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) | Homo sapiens (Human) | |
| 2 | B (A) | N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide | non-polymer | 489.5 | 1 | Chemie (EN6) | |||
| 3 | C (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 4 | D, E, F, G, H... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 17 | Chemie (OLC) | |||
| 5 | AA, BA, CA, K, W... (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 8 | Chemie (PEG) | |||
| 6 | O (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 7 | DA (A) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 17 - 236 (UniProt: Q9Y2T5)
A: 1003 - 1148 (UniProt: P00323)
A: 261 - 340 (UniProt: Q9Y2T5)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Trp 130 | Ala 130 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1098 | Tyr 98 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 1002 | - | linker |
| Leu 264 | Ala 264 | engineered mutation |
| Gln 278 | Trp 278 | engineered mutation |
| Pro 314 | Cys 314 | engineered mutation |
| Ala 318 | Ser 318 | engineered mutation |
| Asp 321 | Asn 321 | engineered mutation |
| Thr 323 | Val 323 | engineered mutation |
| Glu 341 | - | expression tag |
| Phe 342 | - | expression tag |
| Leu 343 | - | expression tag |
| Glu 344 | - | expression tag |
| Val 345 | - | expression tag |
| Leu 346 | - | expression tag |
| Phe 347 | - | expression tag |
| Gln 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Pro 350 | - | expression tag |
| His 351 | - | expression tag |
| His 352 | - | expression tag |
| His 353 | - | expression tag |
| His 354 | - | expression tag |
| His 355 | - | expression tag |
| His 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52603.4 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 8045.1 | |
| All* | Total formula weight | 60648.5 |
