Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LI0

Crystal structure of GPR52 in complex with agonist c17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0010181	molecular_function	FMN binding
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue EN6 A 1401

Chain	Residue
A	PRO28
A	PHE117
A	TYR185
A	HIS186
A	ASP188
A	ILE189
A	PHE190
A	GLU191
A	PRO296
A	SER299
A	PHE300
A	TYR34
A	THR303
A	ASP38
A	VAL39
A	CYS40
A	THR44
A	ILE47
A	CYS94
A	LEU101

site_id	AC2
Number of Residues	22
Details	binding site for residue FMN A 1402

Chain	Residue
A	TYR140
A	SER1010
A	THR1011
A	THR1012
A	GLY1013
A	ASN1014
A	THR1015
A	SER1058
A	THR1059
A	TRP1060
A	GLY1061
A	ASP1062
A	CYS1093
A	GLY1094
A	ASP1095
A	TRP1098
A	TYR1100
A	PHE1101
A	CYS1102
A	HOH1501
A	HOH1505
A	HOH1513

site_id	AC3
Number of Residues	5
Details	binding site for residue OLC A 1403

Chain	Residue
A	THR82
A	TRP166
A	CYS170
A	ASN295
A	OLC1408

site_id	AC4
Number of Residues	6
Details	binding site for residue OLC A 1404

Chain	Residue
A	PHE89
A	SER100
A	GLU110
A	THR113
A	ARG269
A	LEU298

site_id	AC5
Number of Residues	5
Details	binding site for residue OLC A 1405

Chain	Residue
A	LEU112
A	THR113
A	ARG269
A	SER272
A	MET276

site_id	AC6
Number of Residues	6
Details	binding site for residue OLC A 1406

Chain	Residue
A	HIS103
A	ALA213
A	PHE217
A	CYS220
A	PHE221
A	OLC1407

site_id	AC7
Number of Residues	3
Details	binding site for residue OLC A 1407

Chain	Residue
A	HIS103
A	OLC1406
A	OLC1415

site_id	AC8
Number of Residues	5
Details	binding site for residue OLC A 1408

Chain	Residue
A	GLY30
A	ARG159
A	TRP166
A	THR297
A	OLC1403

site_id	AC9
Number of Residues	2
Details	binding site for residue OLC A 1409

Chain	Residue
A	PHE177
A	PHE178

site_id	AD1
Number of Residues	2
Details	binding site for residue PEG A 1410

Chain	Residue
A	GLY179
A	TRP180

site_id	AD2
Number of Residues	6
Details	binding site for residue OLC A 1411

Chain	Residue
A	HIS73
A	ARG139
A	PHE227
A	ARG231
A	LYS1087
A	ILE1148

site_id	AD3
Number of Residues	3
Details	binding site for residue OLC A 1412

Chain	Residue
A	CYS134
A	VAL137
A	OLC1413

site_id	AD4
Number of Residues	2
Details	binding site for residue OLC A 1413

Chain	Residue
A	TRP130
A	OLC1412

site_id	AD5
Number of Residues	6
Details	binding site for residue FLC A 1414

Chain	Residue
A	VAL108
A	ARG261
A	ARG262
A	MET265
A	ARG269
A	GLY1146

site_id	AD6
Number of Residues	5
Details	binding site for residue OLC A 1415

Chain	Residue
A	VAL219
A	CYS220
A	PHE268
A	TYR275
A	OLC1407

site_id	AD7
Number of Residues	3
Details	binding site for residue OLC A 1416

Chain	Residue
A	ARG269
A	SER320
A	LEU112

site_id	AD8
Number of Residues	6
Details	binding site for residue OLC A 1417

Chain	Residue
A	PHE31
A	HIS33
A	VAL39
A	ILE41
A	PHE42
A	GLU43

site_id	AD9
Number of Residues	3
Details	binding site for residue OLC A 1418

Chain	Residue
A	LEU171
A	PHE178
A	TRP180

site_id	AE1
Number of Residues	1
Details	binding site for residue OLC A 1419

Chain	Residue
A	THR60

site_id	AE2
Number of Residues	3
Details	binding site for residue OLC A 1420

Chain	Residue
A	THR60
A	PHE63
A	PEG1427

site_id	AE3
Number of Residues	3
Details	binding site for residue OLC A 1421

Chain	Residue
A	PHE42
A	VAL46
A	SER308

site_id	AE4
Number of Residues	1
Details	binding site for residue PEG A 1422

Chain	Residue
A	SER338

site_id	AE5
Number of Residues	3
Details	binding site for residue PEG A 1424

Chain	Residue
A	ARG330
A	ASP1106
A	ARG1125

site_id	AE6
Number of Residues	3
Details	binding site for residue PEG A 1426

Chain	Residue
A	ASN150
A	ASP1051
A	ARG1086

site_id	AE7
Number of Residues	2
Details	binding site for residue PEG A 1427

Chain	Residue
A	SER290
A	OLC1420

site_id	AE8
Number of Residues	5
Details	binding site for residue PEG A 1428

Chain	Residue
A	GLN232
A	HIS233
A	THR234
A	LYS235
A	GLU236

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cts..CmefLevlfqgphHhhhhhH

Chain	Residue	Details
A	CYS336-HIS358

site_id	PS00201
Number of Residues	17
Details	FLAVODOXIN Flavodoxin signature. IVYgSTtGnTEytAEtI

Chain	Residue	Details
A	ILE1006-ILE1022

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSMwCLACISVDRYLaI

Chain	Residue	Details
A	VAL127-ILE143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	VAL45-PHE65

site_id	SWS_FT_FI2
Number of Residues	42
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	HIS66-ASP87
A	ASP138-ARG159

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	LEU88-VAL108

site_id	SWS_FT_FI4
Number of Residues	38
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	HIS109-VAL116
A	GLY181-PHE203
A	LEU287-PRO296

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	PHE117-VAL137

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	ILE160-TRP180

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	THR204-PHE224

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	VAL266-LEU286

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	THR297-TYR317

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN20

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)