6LB7

Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Calcium uptake protein 1, mitochondrial	polymer	377	43084.0	2	UniProt (Q9BPX6) Pfam (PF13202)	Homo sapiens (Human)	Atopy-related autoantigen CALC,ara CALC,Calcium-binding atopy-related autoantigen 1
2	B, D (B, D)	Calcium uptake protein 2, mitochondrial	polymer	330	38719.2	2	UniProt (Q8IYU8)	Homo sapiens (Human)	EF-hand domain-containing family member A1
3	E, F (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	G, H, I, J (A, B, C, D)	water	water		18.0	1098	Chemie (HOH)

Sequence modifications

A, C: 97 - 444 (UniProt: Q9BPX6)

PDB	External Database	Details
Met 76	-	expression tag
Gly 77	-	expression tag
Ser 78	-	expression tag
Ser 79	-	expression tag
His 80	-	expression tag
His 81	-	expression tag
His 82	-	expression tag
His 83	-	expression tag
His 84	-	expression tag
His 85	-	expression tag
Ser 86	-	expression tag
Ser 87	-	expression tag
Gly 88	-	expression tag
Leu 89	-	expression tag
Val 90	-	expression tag
Pro 91	-	expression tag
Arg 92	-	expression tag
Gly 93	-	expression tag
Ser 94	-	expression tag
His 95	-	expression tag
Met 96	-	expression tag
Gly 445	-	expression tag
Ser 446	-	expression tag
Gly 447	-	expression tag
Ser 448	-	expression tag
Gly 449	-	expression tag
Ser 450	-	expression tag
Gly 451	-	expression tag
Ser 452	-	expression tag

B, D: 84 - 406 (UniProt: Q8IYU8)

PDB	External Database	Details
Gly 77	-	expression tag
Ser 78	-	expression tag
Gly 79	-	expression tag
Ser 80	-	expression tag
Gly 81	-	expression tag
Ser 82	-	expression tag
Gly 83	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	163606.4
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	163686.5

*Water molecules are not included.