6LB7
Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 501 |
| Chain | Residue |
| A | ASP421 |
| A | ASP423 |
| A | ASN425 |
| A | GLU427 |
| A | GLU432 |
| A | HOH732 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 501 |
| Chain | Residue |
| B | MET191 |
| B | GLU196 |
| B | HOH638 |
| B | ASP185 |
| B | ASP187 |
| B | ASN189 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF |
| Chain | Residue | Details |
| A | ASP231-PHE243 | |
| A | ASP421-PHE433 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 105 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
