6KDB

Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	DNA (cytosine-5)-methyltransferase 3B	polymer	286	32715.9	2	UniProt (Q9UBC3) Pfam (PF00145)	Homo sapiens (Human)	Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB
2	B, C (B, C)	DNA (cytosine-5)-methyltransferase 3-like	polymer	204	23627.1	2	UniProt (Q9UJW3)	Homo sapiens (Human)
3	E, F (E, F)	DNA (25-MER)	polymer	25	7698.0	2		synthetic construct
4	G, H (A, D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
5	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	316	Chemie (HOH)

Sequence modifications

A, D: 571 - 853 (UniProt: Q9UBC3)

PDB	External Database	Details
Gly 568	-	expression tag
His 569	-	expression tag
Met 570	-	expression tag

B, C: 178 - 379 (UniProt: Q9UJW3)

PDB	External Database	Details
Gly 176	-	expression tag
His 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	128081.9
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	128850.7

*Water molecules are not included.