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6KDB

Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site

Functional Information from GO Data
ChainGOidnamespacecontents
A0008168molecular_functionmethyltransferase activity
D0008168molecular_functionmethyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue SAH A 901
ChainResidue
APHE581
AVAL628
AGLY648
APRO650
AARG832
ASER833
ATRP834
AHOH1011
AHOH1032
AHOH1035
AASP582
AGLY583
AILE584
ATHR586
ASER604
AGLU605
AVAL606
AASP627

site_idAC2
Number of Residues19
Detailsbinding site for residue SAH D 901
ChainResidue
DPHE581
DASP582
DGLY583
DILE584
DTHR586
DSER604
DGLU605
DVAL606
DASP627
DVAL628
DGLY648
DPRO650
DARG832
DSER833
DTRP834
DHOH1006
DHOH1012
DHOH1024
DHOH1032

Functional Information from PROSITE/UniProt
site_idPS00094
Number of Residues13
DetailsC5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS
ChainResidueDetails
AASP643-SER655

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues556
DetailsDomain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y6K1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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