6JTZ

Crystal Structure of hRecQ1_D2-Zn-WH containing mutation on beta-hairpin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ATP-dependent DNA helicase Q1	polymer	352	40125.6	2	UniProt (P46063) Pfam (PF00271) Pfam (PF16124) In PDB	Homo sapiens (Human)	DNA helicase,RecQ-like type 1,RecQ1,DNA-dependent ATPase Q1,RecQ protein-like 1
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3		water	water		18.0	139	Chemie (HOH)

Sequence modifications

A, B: 282 - 616 (UniProt: P46063)

PDB	External Database	Details
Met 261	-	initiating methionine
Gly 262	-	expression tag
Ser 263	-	expression tag
Ser 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
Ser 271	-	expression tag
Ser 272	-	expression tag
Gly 273	-	expression tag
Leu 274	-	expression tag
Val 275	-	expression tag
Pro 276	-	expression tag
Arg 277	-	expression tag
Gly 278	-	expression tag
Ser 279	-	expression tag
His 280	-	expression tag
Met 281	-	expression tag
-	Phe 565	deletion
-	Thr 566	deletion
Ala 564	Tyr 568	engineered mutation
-	Ala 569	deletion
-	Thr 570	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80251.3
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	80382.1

*Water molecules are not included.