6J65
Crystal structure of human HINT1 mutant complexing with AP4A II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, E) | Histidine triad nucleotide-binding protein 1 | polymer | 128 | 13957.1 | 4 | UniProt (P49773) Pfam (PF01230) | Homo sapiens (Human) | Adenosine 5'-monophosphoramidase,Protein kinase C inhibitor 1,Protein kinase C-interacting protein 1,PKCI-1 |
| 2 | E (B) | BIS(ADENOSINE)-5'-TETRAPHOSPHATE | non-polymer | 836.4 | 1 | Chemie (B4P) PubChem (24867496) PubChem (44286171) PubChem (54592217) PubChem (58298222) PubChem (194) PubChem (21706) PubChem (118705482) PubChem (6603812) PubChem (11513435) PubChem (11957522) PubChem (13455592) PubChem (146121073) PubChem (171904579) PubChem (6328499) PubChem (10795591) PubChem (13455593) | |||
| 3 | F (E) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) | |||
| 4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 776 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 1 - 126 (UniProt: P49773)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Ala 114 | His 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55828.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1074.7 | |
| All* | Total formula weight | 56903.1 |
