6J65
Crystal structure of human HINT1 mutant complexing with AP4A II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, E | Histidine triad nucleotide-binding protein 1 | polymer | 128 | 13957.1 | 4 | UniProt (P49773) Pfam (PF01230) In PDB | Homo sapiens (Human) | Adenosine 5'-monophosphoramidase,Protein kinase C inhibitor 1,Protein kinase C-interacting protein 1,PKCI-1 |
| 2 | B | BIS(ADENOSINE)-5'-TETRAPHOSPHATE | non-polymer | 836.4 | 1 | Chemie (B4P) | |||
| 3 | E | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | water | water | 18.0 | 776 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 1 - 126 (UniProt: P49773)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Ala 114 | His 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55828.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1074.7 | |
| All* | Total formula weight | 56903.1 |
