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6J65

Crystal structure of human HINT1 mutant complexing with AP4A II

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0005080molecular_functionprotein kinase C binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0008234molecular_functioncysteine-type peptidase activity
A0009154biological_processpurine ribonucleotide catabolic process
A0016787molecular_functionhydrolase activity
A0016926biological_processprotein desumoylation
A0016929molecular_functiondeSUMOylase activity
A0043530molecular_functionadenosine 5'-monophosphoramidase activity
A0050850biological_processpositive regulation of calcium-mediated signaling
A0070062cellular_componentextracellular exosome
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0000118cellular_componenthistone deacetylase complex
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0005080molecular_functionprotein kinase C binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006355biological_processregulation of DNA-templated transcription
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0008234molecular_functioncysteine-type peptidase activity
B0009154biological_processpurine ribonucleotide catabolic process
B0016787molecular_functionhydrolase activity
B0016926biological_processprotein desumoylation
B0016929molecular_functiondeSUMOylase activity
B0043530molecular_functionadenosine 5'-monophosphoramidase activity
B0050850biological_processpositive regulation of calcium-mediated signaling
B0070062cellular_componentextracellular exosome
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
D0000118cellular_componenthistone deacetylase complex
D0000166molecular_functionnucleotide binding
D0003824molecular_functioncatalytic activity
D0005080molecular_functionprotein kinase C binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006355biological_processregulation of DNA-templated transcription
D0006508biological_processproteolysis
D0006915biological_processapoptotic process
D0007165biological_processsignal transduction
D0008234molecular_functioncysteine-type peptidase activity
D0009154biological_processpurine ribonucleotide catabolic process
D0016787molecular_functionhydrolase activity
D0016926biological_processprotein desumoylation
D0016929molecular_functiondeSUMOylase activity
D0043530molecular_functionadenosine 5'-monophosphoramidase activity
D0050850biological_processpositive regulation of calcium-mediated signaling
D0070062cellular_componentextracellular exosome
D0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
E0000118cellular_componenthistone deacetylase complex
E0000166molecular_functionnucleotide binding
E0003824molecular_functioncatalytic activity
E0005080molecular_functionprotein kinase C binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0006355biological_processregulation of DNA-templated transcription
E0006508biological_processproteolysis
E0006915biological_processapoptotic process
E0007165biological_processsignal transduction
E0008234molecular_functioncysteine-type peptidase activity
E0009154biological_processpurine ribonucleotide catabolic process
E0016787molecular_functionhydrolase activity
E0016926biological_processprotein desumoylation
E0016929molecular_functiondeSUMOylase activity
E0043530molecular_functionadenosine 5'-monophosphoramidase activity
E0050850biological_processpositive regulation of calcium-mediated signaling
E0070062cellular_componentextracellular exosome
E0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues36
Detailsbinding site for residue B4P B 201
ChainResidue
BILE18
BSER107
BVAL108
BHIS112
BHOH303
BHOH307
BHOH310
BHOH320
BHOH344
BHOH355
BHOH356
BPHE19
BHOH371
BHOH375
BHOH377
BHOH384
BHOH388
BHOH407
BHOH412
BHOH413
EILE18
EILE22
BPHE41
EILE44
ESER107
EVAL108
EEPE201
EHOH301
EHOH363
EHOH378
BHIS42
BASP43
BILE44
BSER45
BLEU53
BGLY105

site_idAC2
Number of Residues11
Detailsbinding site for residue EPE E 201
ChainResidue
BTHR17
BILE18
BILE44
BVAL108
BB4P201
ESER107
EVAL108
ETYR109
EHOH301
EHOH331
EHOH398

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269|PubMed:9323207
ChainResidueDetails
AHIS112
BHIS112
DHIS112
EHIS112

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:22869114, ECO:0007744|PDB:3TW2
ChainResidueDetails
AASP43
DASN99
DGLY105
DHIS112
EASP43
EASN99
EGLY105
EHIS112
AASN99
AGLY105
AHIS112
BASP43
BASN99
BGLY105
BHIS112
DASP43

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2
DALA2
EALA2

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS21
ALYS30
BLYS21
BLYS30
DLYS21
DLYS30
ELYS21
ELYS30

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70349
ChainResidueDetails
ASER45
ASER72
BSER45
BSER72
DSER45
DSER72
ESER45
ESER72

223166

PDB entries from 2024-07-31

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