Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6J65

Crystal structure of human HINT1 mutant complexing with AP4A II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005080	molecular_function	protein kinase C binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0009154	biological_process	purine ribonucleotide catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016926	biological_process	protein desumoylation
A	0016929	molecular_function	deSUMOylase activity
A	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0070062	cellular_component	extracellular exosome
A	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
B	0000118	cellular_component	histone deacetylase complex
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0005080	molecular_function	protein kinase C binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0007165	biological_process	signal transduction
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0009154	biological_process	purine ribonucleotide catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016926	biological_process	protein desumoylation
B	0016929	molecular_function	deSUMOylase activity
B	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
B	0050850	biological_process	positive regulation of calcium-mediated signaling
B	0070062	cellular_component	extracellular exosome
B	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
D	0000118	cellular_component	histone deacetylase complex
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0005080	molecular_function	protein kinase C binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0007165	biological_process	signal transduction
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0009154	biological_process	purine ribonucleotide catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016926	biological_process	protein desumoylation
D	0016929	molecular_function	deSUMOylase activity
D	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
D	0050850	biological_process	positive regulation of calcium-mediated signaling
D	0070062	cellular_component	extracellular exosome
D	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
E	0000118	cellular_component	histone deacetylase complex
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0005080	molecular_function	protein kinase C binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0007165	biological_process	signal transduction
E	0008233	molecular_function	peptidase activity
E	0008234	molecular_function	cysteine-type peptidase activity
E	0009154	biological_process	purine ribonucleotide catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016926	biological_process	protein desumoylation
E	0016929	molecular_function	deSUMOylase activity
E	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
E	0050850	biological_process	positive regulation of calcium-mediated signaling
E	0070062	cellular_component	extracellular exosome
E	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	binding site for residue B4P B 201

Chain	Residue
B	ILE18
B	SER107
B	VAL108
B	HIS112
B	HOH303
B	HOH307
B	HOH310
B	HOH320
B	HOH344
B	HOH355
B	HOH356
B	PHE19
B	HOH371
B	HOH375
B	HOH377
B	HOH384
B	HOH388
B	HOH407
B	HOH412
B	HOH413
E	ILE18
E	ILE22
B	PHE41
E	ILE44
E	SER107
E	VAL108
E	EPE201
E	HOH301
E	HOH363
E	HOH378
B	HIS42
B	ASP43
B	ILE44
B	SER45
B	LEU53
B	GLY105

site_id	AC2
Number of Residues	11
Details	binding site for residue EPE E 201

Chain	Residue
B	THR17
B	ILE18
B	ILE44
B	VAL108
B	B4P201
E	SER107
E	VAL108
E	TYR109
E	HOH301
E	HOH331
E	HOH398

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	432
Details	Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"9323207","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22869114","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TW2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)