6I81
Crystal Structure of the second bromodomain of BRD2 in complex with RT56
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 110 | 12988.9 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | B (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | [1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]phenyl]piperidin-4-yl]-trimethyl-azanium | non-polymer | 613.2 | 1 | Chemie (H7E) | |||
| 5 | E (A) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 346 | - | expression tag |
| Met 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12988.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 870.5 | |
| All* | Total formula weight | 13859.4 |
