6I81
Crystal Structure of the second bromodomain of BRD2 in complex with RT56
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MES A 501 |
| Chain | Residue |
| A | LYS363 |
| A | GLY382 |
| A | LEU383 |
| A | HIS384 |
| A | ASP385 |
| A | TYR428 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | GLU413 |
| A | HOH644 |
| A | HOH662 |
| A | LYS402 |
| A | LYS402 |
| A | ASP407 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue H7E A 503 |
| Chain | Residue |
| A | LYS363 |
| A | LYS364 |
| A | TRP370 |
| A | TRP370 |
| A | PRO371 |
| A | PHE372 |
| A | ASN429 |
| A | HIS433 |
| A | ASP434 |
| A | VAL435 |
| A | HOH604 |
| A | HOH634 |
| A | HOH653 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 |
