6I5N
Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Suppressor of cytokine signaling 2 | polymer | 169 | 19412.0 | 2 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) | Homo sapiens (Human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
| 2 | B, E (B, E) | Elongin-B | polymer | 104 | 11852.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C, F (C, F) | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | G, H, I, J (J, K, I, L) | Growth hormone receptor peptide | polymer | 11 | 1320.4 | 4 | Homo sapiens | ||
| 5 | K, L (A, D) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 6 | M (D) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | N, O, P, Q, R... (A, B, C, D, E...) | water | water | 18.0 | 512 | Chemie (HOH) |
Sequence modifications
A, D: 30 - 198 (UniProt: O14508)
C, F: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 31 | Pro 31 | conflict |
| Ala 115 | Lys 115 | conflict |
| Ala 117 | Lys 117 | conflict |
| Ala 118 | Gln 118 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 89759.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 213.9 | |
| All* | Total formula weight | 89973.5 |
