6I5N

Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0030891	cellular_component	VCB complex
B	0070449	cellular_component	elongin complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0035556	biological_process	intracellular signal transduction
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0030891	cellular_component	VCB complex
E	0070449	cellular_component	elongin complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CO A 201

Chain	Residue
A	HIS149
A	HOH338
A	HOH365
A	HOH383
K	HIS4
K	HOH108

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CO D 201

Chain	Residue
D	HIS149
L	SER2
L	HIS4

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 D 202

Chain	Residue
D	GLN45
D	SER162
D	ARG168
D	TYR190
D	HOH339

---

site_id	AC4
Number of Residues	18
Details	binding site for Di-peptide PTR I 0 and THR I 1

Chain	Residue
A	VAL55
A	ARG73
A	SER75
A	SER76
A	THR83
A	THR93
A	ASN94
A	LEU95
A	ARG96
I	VAL-3
I	PRO-2
I	ASP-1
I	SER2
I	HOH101
I	HOH102
K	ILE5
K	VLM6
K	HOH106

---

site_id	AC5
Number of Residues	6
Details	binding site for Di-peptide ILE I 5 and VLM I 6

Chain	Residue
A	HOH361
C	MET45
I	HIS4
I	HOH104
K	SER2
K	ILE3

---

site_id	AC6
Number of Residues	14
Details	binding site for Di-peptide ASP I -1 and PTR I 0

Chain	Residue
A	VAL55
A	ARG73
A	SER75
A	SER76
A	THR83
A	THR93
A	ASN94
A	ARG96
A	HOH351
I	PRO-2
I	THR1
I	HOH102
I	HOH103
K	HOH106

---

site_id	AC7
Number of Residues	16
Details	binding site for Di-peptide PTR J 0 and THR J 1

Chain	Residue
D	VAL55
D	ARG73
D	SER75
D	SER76
D	THR83
D	THR93
D	ASN94
D	LEU95
D	ARG96
J	VAL-3
J	PRO-2
J	ASP-1
J	SER2
J	HOH101
L	ILE5
L	VLM6

---

site_id	AC8
Number of Residues	10
Details	binding site for Di-peptide ASP J -1 and PTR J 0

Chain	Residue
D	VAL55
D	ARG73
D	SER75
D	SER76
D	THR83
D	THR93
D	ASN94
D	ARG96
J	PRO-2
J	THR1

---

site_id	AC9
Number of Residues	12
Details	binding site for Di-peptide PTR K 0 and THR K 1

Chain	Residue
A	MET132
A	CAS133
A	ASP135
A	LYS136
A	HIS149
A	HOH367
K	ASP-1
K	PRO-2
K	SER2
K	ILE3
K	HOH104
K	HOH107

---

site_id	AD1
Number of Residues	11
Details	binding site for Di-peptide ILE K 5 and VLM K 6

Chain	Residue
K	HOH106
K	HOH109
A	THR88
A	ILE109
A	VAL148
I	THR1
I	SER2
I	ILE3
K	HIS4
K	HOH102
K	HOH103

---

site_id	AD2
Number of Residues	11
Details	binding site for Di-peptide ASP K -1 and PTR K 0

Chain	Residue
A	MET132
A	ASP135
A	LYS136
A	HIS149
A	HOH367
K	PRO-2
K	VAL-3
K	THR1
K	SER2
K	HOH107
K	HOH110

---

site_id	AD3
Number of Residues	7
Details	binding site for Di-peptide PTR L 0 and THR L 1

Chain	Residue
D	MET132
D	CAS133
D	HIS149
L	PRO-2
L	ASP-1
L	SER2
L	ILE3

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ILE L 5 and VLM L 6

Chain	Residue
D	VAL148
D	LEU150
J	THR1
J	SER2
J	ILE3
L	HIS4
L	HOH101

---

site_id	AD5
Number of Residues	6
Details	binding site for Di-peptide ASP L -1 and PTR L 0

Chain	Residue
D	MET132
D	CAS133
D	HIS149
L	PRO-2
L	THR1
L	HOH102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"31578312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31578312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	130
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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