6GVW

Crystal structure of the BRCA1-A complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	BRCA1-A complex subunit Abraxas 1	polymer	411	46431.4	2	UniProt (Q8BPZ8) Pfam (PF21125) In PDB	Mus musculus (House mouse)	Coiled-coil domain-containing protein 98,Protein FAM175A
2	B, G	Lys-63-specific deubiquitinase BRCC36	polymer	295	33711.4	2	UniProt (P46737) Pfam (PF01398) Pfam (PF18110) In PDB	Mus musculus (House mouse)	BRCA1-A complex subunit BRCC36,BRCA1/BRCA2-containing complex subunit 3,BRCA1/BRCA2-containing complex subunit 36,BRISC complex subunit BRCC36
3	C, H	BRISC and BRCA1-A complex member 2	polymer	387	43915.8	2	UniProt (Q8K3W0) Pfam (PF06113) In PDB	Mus musculus (House mouse)	BRCA1-A complex subunit BRE,BRCA1/BRCA2-containing complex subunit 45,Brain and reproductive organ-expressed protein
4	D, I	BRISC and BRCA1-A complex member 1	polymer	337	37155.4	2	UniProt (Q3UI43) In PDB	Mus musculus (House mouse)	Mediator of RAP80 interactions and targeting subunit of 40 kDa,New component of the BRCA1-A complex
5	E, J	BRCA1-A complex subunit RAP80	polymer	64	7327.5	2	UniProt (Q5U5Q9) In PDB	Mus musculus (House mouse)	Receptor-associated protein 80,Ubiquitin interaction motif-containing protein 1
6	B, G	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7		water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, F: 1 - 407 (UniProt: Q8BPZ8)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

B, G: 1 - 291 (UniProt: P46737)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

C, H: 1 - 383 (UniProt: Q8K3W0)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

D, I: 1 - 333 (UniProt: Q3UI43)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

E, J: 275 - 334 (UniProt: Q5U5Q9)

PDB	External Database	Details
Gly 271	-	expression tag
Gly 272	-	expression tag
Gly 273	-	expression tag
Arg 274	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	337083.2
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	337214.0

*Water molecules are not included.