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6GVW

Crystal structure of the BRCA1-A complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006302biological_processdouble-strand break repair
A0006325biological_processchromatin organization
A0007095biological_processmitotic G2 DNA damage checkpoint signaling
A0008017molecular_functionmicrotubule binding
A0008608biological_processattachment of spindle microtubules to kinetochore
A0010212biological_processresponse to ionizing radiation
A0016604cellular_componentnuclear body
A0031593molecular_functionpolyubiquitin modification-dependent protein binding
A0044818biological_processmitotic G2/M transition checkpoint
A0045739biological_processpositive regulation of DNA repair
A0070531cellular_componentBRCA1-A complex
A0070536biological_processprotein K63-linked deubiquitination
A0090307biological_processmitotic spindle assembly
B0000151cellular_componentubiquitin ligase complex
B0000152cellular_componentnuclear ubiquitin ligase complex
B0000922cellular_componentspindle pole
B0004843molecular_functioncysteine-type deubiquitinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006302biological_processdouble-strand break repair
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006508biological_processproteolysis
B0007095biological_processmitotic G2 DNA damage checkpoint signaling
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0010165biological_processresponse to X-ray
B0010212biological_processresponse to ionizing radiation
B0030234molecular_functionenzyme regulator activity
B0031593molecular_functionpolyubiquitin modification-dependent protein binding
B0044818biological_processmitotic G2/M transition checkpoint
B0045739biological_processpositive regulation of DNA repair
B0046872molecular_functionmetal ion binding
B0051301biological_processcell division
B0070531cellular_componentBRCA1-A complex
B0070536biological_processprotein K63-linked deubiquitination
B0070552cellular_componentBRISC complex
B0071479biological_processcellular response to ionizing radiation
B0140492molecular_functionmetal-dependent deubiquitinase activity
B0140861biological_processDNA repair-dependent chromatin remodeling
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B2000001biological_processregulation of DNA damage checkpoint
C0000152cellular_componentnuclear ubiquitin ligase complex
C0005164molecular_functiontumor necrosis factor receptor binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006302biological_processdouble-strand break repair
C0006325biological_processchromatin organization
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007095biological_processmitotic G2 DNA damage checkpoint signaling
C0010212biological_processresponse to ionizing radiation
C0031593molecular_functionpolyubiquitin modification-dependent protein binding
C0043066biological_processnegative regulation of apoptotic process
C0044818biological_processmitotic G2/M transition checkpoint
C0045739biological_processpositive regulation of DNA repair
C0051301biological_processcell division
C0070531cellular_componentBRCA1-A complex
C0070552cellular_componentBRISC complex
C0071479biological_processcellular response to ionizing radiation
C2000001biological_processregulation of DNA damage checkpoint
D0003674molecular_functionmolecular_function
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006282biological_processregulation of DNA repair
D0006302biological_processdouble-strand break repair
D0006325biological_processchromatin organization
D0007095biological_processmitotic G2 DNA damage checkpoint signaling
D0010212biological_processresponse to ionizing radiation
D0016604cellular_componentnuclear body
D0044818biological_processmitotic G2/M transition checkpoint
D0045739biological_processpositive regulation of DNA repair
D0051301biological_processcell division
D0070531cellular_componentBRCA1-A complex
D0070552cellular_componentBRISC complex
D0071425biological_processhematopoietic stem cell proliferation
D0140861biological_processDNA repair-dependent chromatin remodeling
E0006302biological_processdouble-strand break repair
E0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
E0070531cellular_componentBRCA1-A complex
F0005634cellular_componentnucleus
F0006281biological_processDNA repair
F0006282biological_processregulation of DNA repair
F0006302biological_processdouble-strand break repair
F0006325biological_processchromatin organization
F0007095biological_processmitotic G2 DNA damage checkpoint signaling
F0008017molecular_functionmicrotubule binding
F0008608biological_processattachment of spindle microtubules to kinetochore
F0010212biological_processresponse to ionizing radiation
F0016604cellular_componentnuclear body
F0031593molecular_functionpolyubiquitin modification-dependent protein binding
F0044818biological_processmitotic G2/M transition checkpoint
F0045739biological_processpositive regulation of DNA repair
F0070531cellular_componentBRCA1-A complex
F0070536biological_processprotein K63-linked deubiquitination
F0090307biological_processmitotic spindle assembly
G0000151cellular_componentubiquitin ligase complex
G0000152cellular_componentnuclear ubiquitin ligase complex
G0000922cellular_componentspindle pole
G0004843molecular_functioncysteine-type deubiquitinase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005856cellular_componentcytoskeleton
G0006281biological_processDNA repair
G0006282biological_processregulation of DNA repair
G0006302biological_processdouble-strand break repair
G0006325biological_processchromatin organization
G0006338biological_processchromatin remodeling
G0006508biological_processproteolysis
G0007095biological_processmitotic G2 DNA damage checkpoint signaling
G0008233molecular_functionpeptidase activity
G0008237molecular_functionmetallopeptidase activity
G0010165biological_processresponse to X-ray
G0010212biological_processresponse to ionizing radiation
G0030234molecular_functionenzyme regulator activity
G0031593molecular_functionpolyubiquitin modification-dependent protein binding
G0044818biological_processmitotic G2/M transition checkpoint
G0045739biological_processpositive regulation of DNA repair
G0046872molecular_functionmetal ion binding
G0051301biological_processcell division
G0070531cellular_componentBRCA1-A complex
G0070536biological_processprotein K63-linked deubiquitination
G0070552cellular_componentBRISC complex
G0071479biological_processcellular response to ionizing radiation
G0140492molecular_functionmetal-dependent deubiquitinase activity
G0140861biological_processDNA repair-dependent chromatin remodeling
G1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
G2000001biological_processregulation of DNA damage checkpoint
H0000152cellular_componentnuclear ubiquitin ligase complex
H0005164molecular_functiontumor necrosis factor receptor binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006281biological_processDNA repair
H0006282biological_processregulation of DNA repair
H0006302biological_processdouble-strand break repair
H0006325biological_processchromatin organization
H0006915biological_processapoptotic process
H0006974biological_processDNA damage response
H0007095biological_processmitotic G2 DNA damage checkpoint signaling
H0010212biological_processresponse to ionizing radiation
H0031593molecular_functionpolyubiquitin modification-dependent protein binding
H0043066biological_processnegative regulation of apoptotic process
H0044818biological_processmitotic G2/M transition checkpoint
H0045739biological_processpositive regulation of DNA repair
H0051301biological_processcell division
H0070531cellular_componentBRCA1-A complex
H0070552cellular_componentBRISC complex
H0071479biological_processcellular response to ionizing radiation
H2000001biological_processregulation of DNA damage checkpoint
I0003674molecular_functionmolecular_function
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006281biological_processDNA repair
I0006282biological_processregulation of DNA repair
I0006302biological_processdouble-strand break repair
I0006325biological_processchromatin organization
I0007095biological_processmitotic G2 DNA damage checkpoint signaling
I0010212biological_processresponse to ionizing radiation
I0016604cellular_componentnuclear body
I0044818biological_processmitotic G2/M transition checkpoint
I0045739biological_processpositive regulation of DNA repair
I0051301biological_processcell division
I0070531cellular_componentBRCA1-A complex
I0070552cellular_componentBRISC complex
I0071425biological_processhematopoietic stem cell proliferation
I0140861biological_processDNA repair-dependent chromatin remodeling
J0006302biological_processdouble-strand break repair
J0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
J0070531cellular_componentBRCA1-A complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN B 301
ChainResidue
BHIS122
BHIS124
BASP135
BHOH1000

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN G 301
ChainResidue
GHIS122
GHIS124
GASP135
GHOH1000

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:Q9NWV8
ChainResidueDetails
DMET1
IMET1
BASP135
GHIS122
GHIS124
GASP135

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5XIJ6
ChainResidueDetails
DSER8
ISER8
ASER404
FSER384
FSER385
FSER404

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NWV8
ChainResidueDetails
DSER33
DSER53
ISER33
ISER53

223532

PDB entries from 2024-08-07

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