6GHD
Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (G, H) | Emerin | polymer | 45 | 5324.9 | 2 | UniProt (P50402) Pfam (PF03020) | Homo sapiens (Human) | |
| 2 | B, D, E, F (D, E, A, C) | Barrier-to-autointegration factor | polymer | 88 | 9814.1 | 4 | UniProt (O75531) Pfam (PF02961) | Homo sapiens (Human) | Breakpoint cluster region protein 1 |
| 3 | C, G (B, F) | Prelamin-A/C | polymer | 119 | 13206.8 | 2 | UniProt (P02545) Pfam (PF00932) | Homo sapiens (Human) | |
| 4 | I, J, K, L, M... (G, D, E, A, C...) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | O (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | R, S, T, U, V... (G, D, B, E, A...) | water | water | 18.0 | 280 | Chemie (HOH) |
Sequence modifications
G, H: 2 - 45 (UniProt: P50402)
D, E, A, C: 2 - 89 (UniProt: O75531)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 67 | Cys 67 | engineered mutation |
| Ala 77 | Cys 77 | engineered mutation |
| Ala 80 | Cys 80 | engineered mutation |
| Ala 85 | Cys 85 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 76319.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 830.6 | |
| All* | Total formula weight | 77150.5 |
