Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GHD

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000793	cellular_component	condensed chromosome
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0006979	biological_process	response to oxidative stress
A	0007084	biological_process	mitotic nuclear membrane reassembly
A	0009615	biological_process	response to virus
A	0010836	biological_process	negative regulation of protein ADP-ribosylation
A	0015074	biological_process	DNA integration
A	0032480	biological_process	negative regulation of type I interferon production
A	0032481	biological_process	positive regulation of type I interferon production
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045071	biological_process	negative regulation of viral genome replication
A	0045824	biological_process	negative regulation of innate immune response
A	0051276	biological_process	chromosome organization
A	0140896	biological_process	cGAS/STING signaling pathway
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	0000785	cellular_component	chromatin
C	0000793	cellular_component	condensed chromosome
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0006979	biological_process	response to oxidative stress
C	0007084	biological_process	mitotic nuclear membrane reassembly
C	0009615	biological_process	response to virus
C	0010836	biological_process	negative regulation of protein ADP-ribosylation
C	0015074	biological_process	DNA integration
C	0032480	biological_process	negative regulation of type I interferon production
C	0032481	biological_process	positive regulation of type I interferon production
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0045071	biological_process	negative regulation of viral genome replication
C	0045824	biological_process	negative regulation of innate immune response
C	0051276	biological_process	chromosome organization
C	0140896	biological_process	cGAS/STING signaling pathway
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
D	0000785	cellular_component	chromatin
D	0000793	cellular_component	condensed chromosome
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0006979	biological_process	response to oxidative stress
D	0007084	biological_process	mitotic nuclear membrane reassembly
D	0009615	biological_process	response to virus
D	0010836	biological_process	negative regulation of protein ADP-ribosylation
D	0015074	biological_process	DNA integration
D	0032480	biological_process	negative regulation of type I interferon production
D	0032481	biological_process	positive regulation of type I interferon production
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0045071	biological_process	negative regulation of viral genome replication
D	0045824	biological_process	negative regulation of innate immune response
D	0051276	biological_process	chromosome organization
D	0140896	biological_process	cGAS/STING signaling pathway
D	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
E	0000785	cellular_component	chromatin
E	0000793	cellular_component	condensed chromosome
E	0003677	molecular_function	DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006979	biological_process	response to oxidative stress
E	0007084	biological_process	mitotic nuclear membrane reassembly
E	0009615	biological_process	response to virus
E	0010836	biological_process	negative regulation of protein ADP-ribosylation
E	0015074	biological_process	DNA integration
E	0032480	biological_process	negative regulation of type I interferon production
E	0032481	biological_process	positive regulation of type I interferon production
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0045071	biological_process	negative regulation of viral genome replication
E	0045824	biological_process	negative regulation of innate immune response
E	0051276	biological_process	chromosome organization
E	0140896	biological_process	cGAS/STING signaling pathway
E	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
G	0005635	cellular_component	nuclear envelope
H	0005635	cellular_component	nuclear envelope

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 G 101

Chain	Residue
F	ARG482
G	ARG17
G	HIS23
G	HOH201
G	HOH206

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 D 101

Chain	Residue
D	GLN73
D	GLY27
D	GLU28
D	VAL29
D	LEU30

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 D 102

Chain	Residue
D	ARG60
D	ARG75

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 E 101

Chain	Residue
E	SER4
E	LYS6
E	ALA24
E	GLY25
E	ASP76
E	HOH207
E	HOH211
E	HOH222

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 E 102

Chain	Residue
C	GLY27
C	GLU28
C	VAL29
E	ARG60
E	ARG75
E	HOH216

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 101

Chain	Residue
A	SER4
A	ALA24
A	GLY25
A	HOH203
A	HOH221

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 102

Chain	Residue
A	ARG60
A	ARG75
D	LYS6
D	HOH203

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 C 101

Chain	Residue
C	ARG60
C	ARG75

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 H 101

Chain	Residue
B	ARG482
H	ARG17
H	HIS23
H	HOH201
H	HOH208

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	SER429
B	SER533
F	SER429
F	SER533
A	THR2
A	THR3
C	THR2
C	THR3

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
B	SER431
F	SER431
A	SER4
C	SER4

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
B	LYS450
F	LYS450

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P48678

Chain	Residue	Details
B	LYS457
B	LYS486
F	LYS457
F	LYS486

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:24741066, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER458
F	SER458

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER463
F	SER463

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P48679

Chain	Residue	Details
B	THR496
B	THR510
F	THR496
F	THR510

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
B	THR505
F	THR505

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P48678

Chain	Residue	Details
B	SER546
F	SER546

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
B	LYS450
F	LYS450

site_id	SWS_FT_FI11
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
B	LYS470
B	LYS486
F	LYS470
F	LYS486

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)