6FP6

Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Superoxide dismutase [Cu-Zn]	polymer	153	15763.4	12	UniProt (P00441) Pfam (PF00080) In PDB	Homo sapiens (Human)	Superoxide dismutase 1,hSod1
2	B, D, F, H, J...	Copper chaperone for superoxide dismutase	polymer	274	28977.4	12	UniProt (O14618) Pfam (PF00403) Pfam (PF00080) In PDB	Homo sapiens (Human)	Superoxide dismutase copper chaperone
3	V, W, B, X, C...	ZINC ION	non-polymer		65.4	24	Chemie (ZN)
4	A, I, K, R	PROPANOIC ACID	non-polymer		74.1	6	Chemie (PPI)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6		water	water		18.0	75	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K, M, O, Q, S, U, W: 1 - 153 (UniProt: P00441)

PDB	External Database	Details
Ala 57	Cys 58	engineered mutation
Ala 146	Cys 147	engineered mutation

B, D, F, H, J, L, N, P, R, T, V, X: 1 - 274 (UniProt: O14618)

PDB	External Database	Details
Ala 12	Cys 12	engineered mutation
Ala 22	Cys 22	engineered mutation
Ala 25	Cys 25	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	536890.0
Non-Polymers*	Number of molecules	31
	Total formula weight	2106.4
All*	Total formula weight	538996.4

*Water molecules are not included.