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6FP6

Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001541biological_processovarian follicle development
A0001819biological_processpositive regulation of cytokine production
A0001890biological_processplacenta development
A0001895biological_processretina homeostasis
A0002262biological_processmyeloid cell homeostasis
A0004784molecular_functionsuperoxide dismutase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007283biological_processspermatogenesis
A0007566biological_processembryo implantation
A0007605biological_processsensory perception of sound
A0007626biological_processlocomotory behavior
A0008089biological_processanterograde axonal transport
A0008090biological_processretrograde axonal transport
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0008340biological_processdetermination of adult lifespan
A0009408biological_processresponse to heat
A0009410biological_processresponse to xenobiotic stimulus
A0010467biological_processgene expression
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019226biological_processtransmission of nerve impulse
A0019228biological_processneuronal action potential
A0019430biological_processremoval of superoxide radicals
A0030346molecular_functionprotein phosphatase 2B binding
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0032287biological_processperipheral nervous system myelin maintenance
A0032839cellular_componentdendrite cytoplasm
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033081biological_processregulation of T cell differentiation in thymus
A0035234biological_processectopic germ cell programmed cell death
A0040014biological_processregulation of multicellular organism growth
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043087biological_processregulation of GTPase activity
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046620biological_processregulation of organ growth
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048538biological_processthymus development
A0048678biological_processresponse to axon injury
A0050665biological_processhydrogen peroxide biosynthetic process
A0050728biological_processnegative regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0051087molecular_functionprotein-folding chaperone binding
A0051093biological_processnegative regulation of developmental process
A0051881biological_processregulation of mitochondrial membrane potential
A0060047biological_processheart contraction
A0060052biological_processneurofilament cytoskeleton organization
A0060087biological_processrelaxation of vascular associated smooth muscle
A0060088biological_processauditory receptor cell stereocilium organization
A0070062cellular_componentextracellular exosome
A0072593biological_processreactive oxygen species metabolic process
A0099610biological_processaction potential initiation
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1904115cellular_componentaxon cytoplasm
A2000242biological_processnegative regulation of reproductive process
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006801biological_processsuperoxide metabolic process
B0015035molecular_functionprotein-disulfide reductase activity
B0015680biological_processprotein maturation by copper ion transfer
B0016532molecular_functionsuperoxide dismutase copper chaperone activity
B0019430biological_processremoval of superoxide radicals
B0034599biological_processcellular response to oxidative stress
B0045296molecular_functioncadherin binding
B0046872molecular_functionmetal ion binding
C0000302biological_processresponse to reactive oxygen species
C0000303biological_processresponse to superoxide
C0001541biological_processovarian follicle development
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001895biological_processretina homeostasis
C0002262biological_processmyeloid cell homeostasis
C0004784molecular_functionsuperoxide dismutase activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0005759cellular_componentmitochondrial matrix
C0005777cellular_componentperoxisome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006879biological_processintracellular iron ion homeostasis
C0006915biological_processapoptotic process
C0006979biological_processresponse to oxidative stress
C0007283biological_processspermatogenesis
C0007566biological_processembryo implantation
C0007605biological_processsensory perception of sound
C0007626biological_processlocomotory behavior
C0008089biological_processanterograde axonal transport
C0008090biological_processretrograde axonal transport
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0008340biological_processdetermination of adult lifespan
C0009408biological_processresponse to heat
C0009410biological_processresponse to xenobiotic stimulus
C0010467biological_processgene expression
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019226biological_processtransmission of nerve impulse
C0019228biological_processneuronal action potential
C0019430biological_processremoval of superoxide radicals
C0030346molecular_functionprotein phosphatase 2B binding
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0032287biological_processperipheral nervous system myelin maintenance
C0032839cellular_componentdendrite cytoplasm
C0032930biological_processpositive regulation of superoxide anion generation
C0032991cellular_componentprotein-containing complex
C0033081biological_processregulation of T cell differentiation in thymus
C0035234biological_processectopic germ cell programmed cell death
C0040014biological_processregulation of multicellular organism growth
C0042542biological_processresponse to hydrogen peroxide
C0042554biological_processsuperoxide anion generation
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043087biological_processregulation of GTPase activity
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046620biological_processregulation of organ growth
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048538biological_processthymus development
C0048678biological_processresponse to axon injury
C0050665biological_processhydrogen peroxide biosynthetic process
C0050728biological_processnegative regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0051087molecular_functionprotein-folding chaperone binding
C0051093biological_processnegative regulation of developmental process
C0051881biological_processregulation of mitochondrial membrane potential
C0060047biological_processheart contraction
C0060052biological_processneurofilament cytoskeleton organization
C0060087biological_processrelaxation of vascular associated smooth muscle
C0060088biological_processauditory receptor cell stereocilium organization
C0070062cellular_componentextracellular exosome
C0072593biological_processreactive oxygen species metabolic process
C0099610biological_processaction potential initiation
C1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1904115cellular_componentaxon cytoplasm
C2000242biological_processnegative regulation of reproductive process
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006801biological_processsuperoxide metabolic process
D0015035molecular_functionprotein-disulfide reductase activity
D0015680biological_processprotein maturation by copper ion transfer
D0016532molecular_functionsuperoxide dismutase copper chaperone activity
D0019430biological_processremoval of superoxide radicals
D0034599biological_processcellular response to oxidative stress
D0045296molecular_functioncadherin binding
D0046872molecular_functionmetal ion binding
E0000302biological_processresponse to reactive oxygen species
E0000303biological_processresponse to superoxide
E0001541biological_processovarian follicle development
E0001819biological_processpositive regulation of cytokine production
E0001890biological_processplacenta development
E0001895biological_processretina homeostasis
E0002262biological_processmyeloid cell homeostasis
E0004784molecular_functionsuperoxide dismutase activity
E0005507molecular_functioncopper ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005758cellular_componentmitochondrial intermembrane space
E0005759cellular_componentmitochondrial matrix
E0005777cellular_componentperoxisome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006749biological_processglutathione metabolic process
E0006801biological_processsuperoxide metabolic process
E0006879biological_processintracellular iron ion homeostasis
E0006915biological_processapoptotic process
E0006979biological_processresponse to oxidative stress
E0007283biological_processspermatogenesis
E0007566biological_processembryo implantation
E0007605biological_processsensory perception of sound
E0007626biological_processlocomotory behavior
E0008089biological_processanterograde axonal transport
E0008090biological_processretrograde axonal transport
E0008217biological_processregulation of blood pressure
E0008270molecular_functionzinc ion binding
E0008340biological_processdetermination of adult lifespan
E0009408biological_processresponse to heat
E0009410biological_processresponse to xenobiotic stimulus
E0010467biological_processgene expression
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0019226biological_processtransmission of nerve impulse
E0019228biological_processneuronal action potential
E0019430biological_processremoval of superoxide radicals
E0030346molecular_functionprotein phosphatase 2B binding
E0031267molecular_functionsmall GTPase binding
E0031410cellular_componentcytoplasmic vesicle
E0032287biological_processperipheral nervous system myelin maintenance
E0032839cellular_componentdendrite cytoplasm
E0032930biological_processpositive regulation of superoxide anion generation
E0032991cellular_componentprotein-containing complex
E0033081biological_processregulation of T cell differentiation in thymus
E0035234biological_processectopic germ cell programmed cell death
E0040014biological_processregulation of multicellular organism growth
E0042542biological_processresponse to hydrogen peroxide
E0042554biological_processsuperoxide anion generation
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043025cellular_componentneuronal cell body
E0043065biological_processpositive regulation of apoptotic process
E0043066biological_processnegative regulation of apoptotic process
E0043087biological_processregulation of GTPase activity
E0043410biological_processpositive regulation of MAPK cascade
E0043524biological_processnegative regulation of neuron apoptotic process
E0045471biological_processresponse to ethanol
E0046620biological_processregulation of organ growth
E0046716biological_processmuscle cell cellular homeostasis
E0046872molecular_functionmetal ion binding
E0048538biological_processthymus development
E0048678biological_processresponse to axon injury
E0050665biological_processhydrogen peroxide biosynthetic process
E0050728biological_processnegative regulation of inflammatory response
E0050766biological_processpositive regulation of phagocytosis
E0051087molecular_functionprotein-folding chaperone binding
E0051093biological_processnegative regulation of developmental process
E0051881biological_processregulation of mitochondrial membrane potential
E0060047biological_processheart contraction
E0060052biological_processneurofilament cytoskeleton organization
E0060087biological_processrelaxation of vascular associated smooth muscle
E0060088biological_processauditory receptor cell stereocilium organization
E0070062cellular_componentextracellular exosome
E0072593biological_processreactive oxygen species metabolic process
E0099610biological_processaction potential initiation
E1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1904115cellular_componentaxon cytoplasm
E2000242biological_processnegative regulation of reproductive process
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006801biological_processsuperoxide metabolic process
F0015035molecular_functionprotein-disulfide reductase activity
F0015680biological_processprotein maturation by copper ion transfer
F0016532molecular_functionsuperoxide dismutase copper chaperone activity
F0019430biological_processremoval of superoxide radicals
F0034599biological_processcellular response to oxidative stress
F0045296molecular_functioncadherin binding
F0046872molecular_functionmetal ion binding
G0000302biological_processresponse to reactive oxygen species
G0000303biological_processresponse to superoxide
G0001541biological_processovarian follicle development
G0001819biological_processpositive regulation of cytokine production
G0001890biological_processplacenta development
G0001895biological_processretina homeostasis
G0002262biological_processmyeloid cell homeostasis
G0004784molecular_functionsuperoxide dismutase activity
G0005507molecular_functioncopper ion binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005758cellular_componentmitochondrial intermembrane space
G0005759cellular_componentmitochondrial matrix
G0005777cellular_componentperoxisome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006749biological_processglutathione metabolic process
G0006801biological_processsuperoxide metabolic process
G0006879biological_processintracellular iron ion homeostasis
G0006915biological_processapoptotic process
G0006979biological_processresponse to oxidative stress
G0007283biological_processspermatogenesis
G0007566biological_processembryo implantation
G0007605biological_processsensory perception of sound
G0007626biological_processlocomotory behavior
G0008089biological_processanterograde axonal transport
G0008090biological_processretrograde axonal transport
G0008217biological_processregulation of blood pressure
G0008270molecular_functionzinc ion binding
G0008340biological_processdetermination of adult lifespan
G0009408biological_processresponse to heat
G0009410biological_processresponse to xenobiotic stimulus
G0010467biological_processgene expression
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0019226biological_processtransmission of nerve impulse
G0019228biological_processneuronal action potential
G0019430biological_processremoval of superoxide radicals
G0030346molecular_functionprotein phosphatase 2B binding
G0031267molecular_functionsmall GTPase binding
G0031410cellular_componentcytoplasmic vesicle
G0032287biological_processperipheral nervous system myelin maintenance
G0032839cellular_componentdendrite cytoplasm
G0032930biological_processpositive regulation of superoxide anion generation
G0032991cellular_componentprotein-containing complex
G0033081biological_processregulation of T cell differentiation in thymus
G0035234biological_processectopic germ cell programmed cell death
G0040014biological_processregulation of multicellular organism growth
G0042542biological_processresponse to hydrogen peroxide
G0042554biological_processsuperoxide anion generation
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043025cellular_componentneuronal cell body
G0043065biological_processpositive regulation of apoptotic process
G0043066biological_processnegative regulation of apoptotic process
G0043087biological_processregulation of GTPase activity
G0043410biological_processpositive regulation of MAPK cascade
G0043524biological_processnegative regulation of neuron apoptotic process
G0045471biological_processresponse to ethanol
G0046620biological_processregulation of organ growth
G0046716biological_processmuscle cell cellular homeostasis
G0046872molecular_functionmetal ion binding
G0048538biological_processthymus development
G0048678biological_processresponse to axon injury
G0050665biological_processhydrogen peroxide biosynthetic process
G0050728biological_processnegative regulation of inflammatory response
G0050766biological_processpositive regulation of phagocytosis
G0051087molecular_functionprotein-folding chaperone binding
G0051093biological_processnegative regulation of developmental process
G0051881biological_processregulation of mitochondrial membrane potential
G0060047biological_processheart contraction
G0060052biological_processneurofilament cytoskeleton organization
G0060087biological_processrelaxation of vascular associated smooth muscle
G0060088biological_processauditory receptor cell stereocilium organization
G0070062cellular_componentextracellular exosome
G0072593biological_processreactive oxygen species metabolic process
G0099610biological_processaction potential initiation
G1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G1904115cellular_componentaxon cytoplasm
G2000242biological_processnegative regulation of reproductive process
H0005507molecular_functioncopper ion binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006801biological_processsuperoxide metabolic process
H0015035molecular_functionprotein-disulfide reductase activity
H0015680biological_processprotein maturation by copper ion transfer
H0016532molecular_functionsuperoxide dismutase copper chaperone activity
H0019430biological_processremoval of superoxide radicals
H0034599biological_processcellular response to oxidative stress
H0045296molecular_functioncadherin binding
H0046872molecular_functionmetal ion binding
I0000302biological_processresponse to reactive oxygen species
I0000303biological_processresponse to superoxide
I0001541biological_processovarian follicle development
I0001819biological_processpositive regulation of cytokine production
I0001890biological_processplacenta development
I0001895biological_processretina homeostasis
I0002262biological_processmyeloid cell homeostasis
I0004784molecular_functionsuperoxide dismutase activity
I0005507molecular_functioncopper ion binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005758cellular_componentmitochondrial intermembrane space
I0005759cellular_componentmitochondrial matrix
I0005777cellular_componentperoxisome
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006749biological_processglutathione metabolic process
I0006801biological_processsuperoxide metabolic process
I0006879biological_processintracellular iron ion homeostasis
I0006915biological_processapoptotic process
I0006979biological_processresponse to oxidative stress
I0007283biological_processspermatogenesis
I0007566biological_processembryo implantation
I0007605biological_processsensory perception of sound
I0007626biological_processlocomotory behavior
I0008089biological_processanterograde axonal transport
I0008090biological_processretrograde axonal transport
I0008217biological_processregulation of blood pressure
I0008270molecular_functionzinc ion binding
I0008340biological_processdetermination of adult lifespan
I0009408biological_processresponse to heat
I0009410biological_processresponse to xenobiotic stimulus
I0010467biological_processgene expression
I0016209molecular_functionantioxidant activity
I0016491molecular_functionoxidoreductase activity
I0019226biological_processtransmission of nerve impulse
I0019228biological_processneuronal action potential
I0019430biological_processremoval of superoxide radicals
I0030346molecular_functionprotein phosphatase 2B binding
I0031267molecular_functionsmall GTPase binding
I0031410cellular_componentcytoplasmic vesicle
I0032287biological_processperipheral nervous system myelin maintenance
I0032839cellular_componentdendrite cytoplasm
I0032930biological_processpositive regulation of superoxide anion generation
I0032991cellular_componentprotein-containing complex
I0033081biological_processregulation of T cell differentiation in thymus
I0035234biological_processectopic germ cell programmed cell death
I0040014biological_processregulation of multicellular organism growth
I0042542biological_processresponse to hydrogen peroxide
I0042554biological_processsuperoxide anion generation
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0043025cellular_componentneuronal cell body
I0043065biological_processpositive regulation of apoptotic process
I0043066biological_processnegative regulation of apoptotic process
I0043087biological_processregulation of GTPase activity
I0043410biological_processpositive regulation of MAPK cascade
I0043524biological_processnegative regulation of neuron apoptotic process
I0045471biological_processresponse to ethanol
I0046620biological_processregulation of organ growth
I0046716biological_processmuscle cell cellular homeostasis
I0046872molecular_functionmetal ion binding
I0048538biological_processthymus development
I0048678biological_processresponse to axon injury
I0050665biological_processhydrogen peroxide biosynthetic process
I0050728biological_processnegative regulation of inflammatory response
I0050766biological_processpositive regulation of phagocytosis
I0051087molecular_functionprotein-folding chaperone binding
I0051093biological_processnegative regulation of developmental process
I0051881biological_processregulation of mitochondrial membrane potential
I0060047biological_processheart contraction
I0060052biological_processneurofilament cytoskeleton organization
I0060087biological_processrelaxation of vascular associated smooth muscle
I0060088biological_processauditory receptor cell stereocilium organization
I0070062cellular_componentextracellular exosome
I0072593biological_processreactive oxygen species metabolic process
I0099610biological_processaction potential initiation
I1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I1904115cellular_componentaxon cytoplasm
I2000242biological_processnegative regulation of reproductive process
J0005507molecular_functioncopper ion binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006801biological_processsuperoxide metabolic process
J0015035molecular_functionprotein-disulfide reductase activity
J0015680biological_processprotein maturation by copper ion transfer
J0016532molecular_functionsuperoxide dismutase copper chaperone activity
J0019430biological_processremoval of superoxide radicals
J0034599biological_processcellular response to oxidative stress
J0045296molecular_functioncadherin binding
J0046872molecular_functionmetal ion binding
K0000302biological_processresponse to reactive oxygen species
K0000303biological_processresponse to superoxide
K0001541biological_processovarian follicle development
K0001819biological_processpositive regulation of cytokine production
K0001890biological_processplacenta development
K0001895biological_processretina homeostasis
K0002262biological_processmyeloid cell homeostasis
K0004784molecular_functionsuperoxide dismutase activity
K0005507molecular_functioncopper ion binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005758cellular_componentmitochondrial intermembrane space
K0005759cellular_componentmitochondrial matrix
K0005777cellular_componentperoxisome
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006749biological_processglutathione metabolic process
K0006801biological_processsuperoxide metabolic process
K0006879biological_processintracellular iron ion homeostasis
K0006915biological_processapoptotic process
K0006979biological_processresponse to oxidative stress
K0007283biological_processspermatogenesis
K0007566biological_processembryo implantation
K0007605biological_processsensory perception of sound
K0007626biological_processlocomotory behavior
K0008089biological_processanterograde axonal transport
K0008090biological_processretrograde axonal transport
K0008217biological_processregulation of blood pressure
K0008270molecular_functionzinc ion binding
K0008340biological_processdetermination of adult lifespan
K0009408biological_processresponse to heat
K0009410biological_processresponse to xenobiotic stimulus
K0010467biological_processgene expression
K0016209molecular_functionantioxidant activity
K0016491molecular_functionoxidoreductase activity
K0019226biological_processtransmission of nerve impulse
K0019228biological_processneuronal action potential
K0019430biological_processremoval of superoxide radicals
K0030346molecular_functionprotein phosphatase 2B binding
K0031267molecular_functionsmall GTPase binding
K0031410cellular_componentcytoplasmic vesicle
K0032287biological_processperipheral nervous system myelin maintenance
K0032839cellular_componentdendrite cytoplasm
K0032930biological_processpositive regulation of superoxide anion generation
K0032991cellular_componentprotein-containing complex
K0033081biological_processregulation of T cell differentiation in thymus
K0035234biological_processectopic germ cell programmed cell death
K0040014biological_processregulation of multicellular organism growth
K0042542biological_processresponse to hydrogen peroxide
K0042554biological_processsuperoxide anion generation
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0043025cellular_componentneuronal cell body
K0043065biological_processpositive regulation of apoptotic process
K0043066biological_processnegative regulation of apoptotic process
K0043087biological_processregulation of GTPase activity
K0043410biological_processpositive regulation of MAPK cascade
K0043524biological_processnegative regulation of neuron apoptotic process
K0045471biological_processresponse to ethanol
K0046620biological_processregulation of organ growth
K0046716biological_processmuscle cell cellular homeostasis
K0046872molecular_functionmetal ion binding
K0048538biological_processthymus development
K0048678biological_processresponse to axon injury
K0050665biological_processhydrogen peroxide biosynthetic process
K0050728biological_processnegative regulation of inflammatory response
K0050766biological_processpositive regulation of phagocytosis
K0051087molecular_functionprotein-folding chaperone binding
K0051093biological_processnegative regulation of developmental process
K0051881biological_processregulation of mitochondrial membrane potential
K0060047biological_processheart contraction
K0060052biological_processneurofilament cytoskeleton organization
K0060087biological_processrelaxation of vascular associated smooth muscle
K0060088biological_processauditory receptor cell stereocilium organization
K0070062cellular_componentextracellular exosome
K0072593biological_processreactive oxygen species metabolic process
K0099610biological_processaction potential initiation
K1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K1904115cellular_componentaxon cytoplasm
K2000242biological_processnegative regulation of reproductive process
L0005507molecular_functioncopper ion binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
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W0099610biological_processaction potential initiation
W1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
W1904115cellular_componentaxon cytoplasm
W2000242biological_processnegative regulation of reproductive process
X0005507molecular_functioncopper ion binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0006801biological_processsuperoxide metabolic process
X0015035molecular_functionprotein-disulfide reductase activity
X0015680biological_processprotein maturation by copper ion transfer
X0016532molecular_functionsuperoxide dismutase copper chaperone activity
X0019430biological_processremoval of superoxide radicals
X0034599biological_processcellular response to oxidative stress
X0045296molecular_functioncadherin binding
X0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 201
ChainResidue
AHIS63
AHIS71
AHIS80
AASP83

site_idAC2
Number of Residues3
Detailsbinding site for residue PPI A 202
ChainResidue
AASN26
AHIS110
JGLU186

site_idAC3
Number of Residues4
Detailsbinding site for residue PPI A 203
ChainResidue
EALA89
JASP160
AGLU24
EGLU40

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 204
ChainResidue
AGLU40
AASP90
ALYS91
DASP160
EGLU24

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN B 400
ChainResidue
BHIS147
BHIS155
BHIS164
BASP167

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN C 201
ChainResidue
CHIS63
CHIS71
CHIS80
CASP83
CLYS136

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN D 400
ChainResidue
DHIS147
DHIS155
DHIS164
DASP167

site_idAC8
Number of Residues5
Detailsbinding site for residue ZN E 201
ChainResidue
EHIS63
EHIS71
EHIS80
EASP83
ELYS136

site_idAC9
Number of Residues4
Detailsbinding site for residue ZN F 400
ChainResidue
FHIS147
FHIS155
FHIS164
FASP167

site_idAD1
Number of Residues4
Detailsbinding site for residue ZN G 201
ChainResidue
GHIS63
GHIS71
GHIS80
GASP83

site_idAD2
Number of Residues4
Detailsbinding site for residue ZN H 400
ChainResidue
HHIS147
HHIS155
HHIS164
HASP167

site_idAD3
Number of Residues5
Detailsbinding site for residue ZN I 201
ChainResidue
IHIS63
IHIS71
IHIS80
IASP83
ILYS136

site_idAD4
Number of Residues1
Detailsbinding site for residue PPI I 202
ChainResidue
ITRP32

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN J 400
ChainResidue
JHIS147
JHIS155
JHIS164
JASP167

site_idAD6
Number of Residues5
Detailsbinding site for residue ZN K 201
ChainResidue
KHIS63
KHIS71
KHIS80
KASP83
KLYS136

site_idAD7
Number of Residues6
Detailsbinding site for residue PPI K 202
ChainResidue
GGLU24
KGLU40
KASP90
NGLN159
NASP160
NARG209

site_idAD8
Number of Residues3
Detailsbinding site for residue PPI K 203
ChainResidue
KASP90
KASP92
NASP162

site_idAD9
Number of Residues4
Detailsbinding site for residue ZN L 400
ChainResidue
LHIS147
LHIS155
LHIS164
LASP167

site_idAE1
Number of Residues4
Detailsbinding site for residue ZN M 201
ChainResidue
MHIS63
MHIS71
MHIS80
MASP83

site_idAE2
Number of Residues4
Detailsbinding site for residue ZN N 400
ChainResidue
NHIS147
NHIS155
NHIS164
NASP167

site_idAE3
Number of Residues4
Detailsbinding site for residue ZN O 201
ChainResidue
OHIS63
OHIS71
OHIS80
OASP83

site_idAE4
Number of Residues4
Detailsbinding site for residue ZN P 400
ChainResidue
PHIS147
PHIS155
PHIS164
PASP167

site_idAE5
Number of Residues4
Detailsbinding site for residue ZN Q 201
ChainResidue
QHIS63
QHIS71
QHIS80
QASP83

site_idAE6
Number of Residues4
Detailsbinding site for residue ZN R 301
ChainResidue
RHIS147
RHIS155
RHIS164
RASP167

site_idAE7
Number of Residues7
Detailsbinding site for residue PPI R 302
ChainResidue
OASP90
OLYS91
RGLN159
RASP160
SLYS23
SGLU24
OGLU40

site_idAE8
Number of Residues5
Detailsbinding site for residue ZN S 201
ChainResidue
SHIS63
SHIS71
SHIS80
SASP83
SLYS136

site_idAE9
Number of Residues4
Detailsbinding site for residue ZN T 400
ChainResidue
THIS147
THIS155
THIS164
TASP167

site_idAF1
Number of Residues4
Detailsbinding site for residue ZN U 201
ChainResidue
UHIS63
UHIS71
UHIS80
UASP83

site_idAF2
Number of Residues4
Detailsbinding site for residue ZN V 400
ChainResidue
VHIS147
VHIS155
VHIS164
VASP167

site_idAF3
Number of Residues4
Detailsbinding site for residue ZN W 201
ChainResidue
WHIS63
WHIS71
WHIS80
WASP83

site_idAF4
Number of Residues4
Detailsbinding site for residue ZN X 400
ChainResidue
XHIS147
XHIS155
XHIS164
XASP167

Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT
ChainResidueDetails
AGLY44-THR54

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNSGeRlACgiI
ChainResidueDetails
BGLY219-ILE230

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00280, ECO:0007744|PDB:2RSQ
ChainResidueDetails
BALA22
JALA25
LALA22
LALA25
NALA22
NALA25
PALA22
PALA25
RALA22
RALA25
TALA22
BALA25
TALA25
VALA22
VALA25
XALA22
XALA25
QHIS46
QHIS48
QHIS120
SHIS46
SHIS48
DALA22
SHIS120
UHIS46
UHIS48
UHIS120
WHIS46
WHIS48
WHIS120
DALA25
FALA22
FALA25
HALA22
HALA25
JALA22

site_idSWS_FT_FI2
Number of Residues48
DetailsBINDING: BINDING => ECO:0000269|PubMed:10677207, ECO:0007744|PDB:1DO5
ChainResidueDetails
BHIS147
FHIS155
FHIS164
FASP167
HHIS147
HHIS155
HHIS164
HASP167
JHIS147
JHIS155
JHIS164
BHIS155
JASP167
LHIS147
LHIS155
LHIS164
LASP167
NHIS147
NHIS155
NHIS164
NASP167
PHIS147
BHIS164
PHIS155
PHIS164
PASP167
RHIS147
RHIS155
RHIS164
RASP167
THIS147
THIS155
THIS164
BASP167
TASP167
VHIS147
VHIS155
VHIS164
VASP167
XHIS147
XHIS155
XHIS164
XASP167
DHIS147
DHIS155
DHIS164
DASP167
FHIS147

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING:
ChainResidueDetails
BCYS244
JCYS246
LCYS244
LCYS246
NCYS244
NCYS246
PCYS244
PCYS246
RCYS244
RCYS246
TCYS244
BCYS246
TCYS246
VCYS244
VCYS246
XCYS244
XCYS246
DCYS244
DCYS246
FCYS244
FCYS246
HCYS244
HCYS246
JCYS244

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER267
TSER267
VSER267
XSER267
ILYS3
ILYS9
ILYS91
KLYS3
KLYS9
KLYS91
MLYS3
DSER267
MLYS9
MLYS91
OLYS3
OLYS9
OLYS91
QLYS3
QLYS9
QLYS91
SLYS3
SLYS9
FSER267
SLYS91
ULYS3
ULYS9
ULYS91
WLYS3
WLYS9
WLYS91
HSER267
JSER267
LSER267
NSER267
PSER267
RSER267

site_idSWS_FT_FI5
Number of Residues60
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:20154138
ChainResidueDetails
BLYS76
DLYS241
FLYS76
WSER98
FLYS189
FLYS216
FLYS241
HLYS76
HLYS189
HLYS216
CSER98
HLYS241
JLYS76
JLYS189
JLYS216
JLYS241
LLYS76
LLYS189
LLYS216
BLYS189
LLYS241
NLYS76
NLYS189
NLYS216
NLYS241
PLYS76
PLYS189
PLYS216
BLYS216
PLYS241
RLYS76
RLYS189
RLYS216
RLYS241
TLYS76
TLYS189
TLYS216
BLYS241
TLYS241
VLYS76
VLYS189
VLYS216
VLYS241
XLYS76
XLYS189
XLYS216
DLYS76
XLYS241
MSER98
DLYS189
DLYS216

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER102
SSER102
USER102
WSER102
CSER102
ESER102
GSER102
ISER102
KSER102
MSER102
OSER102
QSER102

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07632
ChainResidueDetails
ASER105
SSER105
USER105
WSER105
CSER105
ESER105
GSER105
ISER105
KSER105
MSER105
OSER105
QSER105

site_idSWS_FT_FI8
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ASER107
SSER107
USER107
WSER107
CSER107
ESER107
GSER107
ISER107
KSER107
MSER107
OSER107
QSER107

site_idSWS_FT_FI9
Number of Residues12
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:24140062
ChainResidueDetails
ALYS122
SLYS122
ULYS122
WLYS122
CLYS122
ELYS122
GLYS122
ILYS122
KLYS122
MLYS122
OLYS122
QLYS122

site_idSWS_FT_FI10
Number of Residues12
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ALYS136
SLYS136
ULYS136
WLYS136
CLYS136
ELYS136
GLYS136
ILYS136
KLYS136
MLYS136
OLYS136
QLYS136

site_idSWS_FT_FI11
Number of Residues12
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22496122
ChainResidueDetails
ACYS6
SCYS6
UCYS6
WCYS6
CCYS6
ECYS6
GCYS6
ICYS6
KCYS6
MCYS6
OCYS6
QCYS6

site_idSWS_FT_FI12
Number of Residues24
DetailsCROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269|PubMed:20600836
ChainResidueDetails
ATRP32
KTRP32
MTRP32
OTRP32
QTRP32
STRP32
UTRP32
WTRP32
CTRP32
ETRP32
GTRP32
ITRP32

223166

PDB entries from 2024-07-31

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