6E2H

Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D	Set1/Ash2 histone methyltransferase complex subunit ASH2	polymer	214	23974.2	1	UniProt (Q9UBL3) Pfam (PF00622) In PDB	Homo sapiens (Human)	ASH2-like protein
2	E, F	Protein dpy-30 homolog	polymer	100	11318.7	2	UniProt (Q9C005) Pfam (PF05186) In PDB	Homo sapiens (Human)	Dpy-30-like protein,Dpy-30L
3		water	water		18.0	188	Chemie (HOH)

Sequence modifications

D: 286 - 491 (UniProt: Q9UBL3)

PDB	External Database	Details
Ala 278	-	expression tag
Thr 279	-	expression tag
Tyr 280	-	expression tag
Ala 281	-	expression tag
Met 282	-	expression tag
Gly 283	-	expression tag
Ser 284	-	expression tag
Met 285	-	expression tag
-	Glu 497	deletion
-	Thr 498	deletion
-	Ala 499	deletion
-	Lys 500	deletion
-	Ser 501	deletion
-	Leu 502	deletion
-	Pro 503	deletion
-	Asp 504	deletion
-	Thr 505	deletion
-	Tyr 506	deletion
-	Lys 507	deletion
-	Asp 508	deletion
-	Lys 509	deletion
-	Ala 510	deletion
-	Leu 511	deletion
-	Ile 512	deletion
-	Lys 513	deletion
-	Phe 514	deletion
-	Lys 515	deletion
-	Ser 516	deletion
-	Tyr 517	deletion
-	Leu 518	deletion
-	Tyr 519	deletion
-	Phe 520	deletion
-	Glu 521	deletion
-	Glu 522	deletion
-	Lys 523	deletion
-	Asp 524	deletion
-	Phe 525	deletion
-	Val 526	deletion
-	Asp 527	deletion
-	Lys 528	deletion
-	Ala 529	deletion
-	Glu 530	deletion
-	Lys 531	deletion
-	Ser 532	deletion
-	Leu 533	deletion
Ile 403	Lys 534	conflict
Ser 404	Gln 535	conflict
Gly 405	Thr 536	conflict
Arg 406	Pro 537	conflict
Gly 407	His 538	conflict

E, F: 1 - 99 (UniProt: Q9C005)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46611.6
All*	Total formula weight	46611.6

*Water molecules are not included.