6E2H

Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0048188	cellular_component	Set1C/COMPASS complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005802	cellular_component	trans-Golgi network
E	0006325	biological_process	chromatin organization
E	0016197	biological_process	endosomal transport
E	0035097	cellular_component	histone methyltransferase complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044665	cellular_component	MLL1/2 complex
E	0044666	cellular_component	MLL3/4 complex
E	0045815	biological_process	transcription initiation-coupled chromatin remodeling
E	0048188	cellular_component	Set1C/COMPASS complex
E	0071339	cellular_component	MLL1 complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005802	cellular_component	trans-Golgi network
F	0006325	biological_process	chromatin organization
F	0016197	biological_process	endosomal transport
F	0035097	cellular_component	histone methyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044665	cellular_component	MLL1/2 complex
F	0044666	cellular_component	MLL3/4 complex
F	0045815	biological_process	transcription initiation-coupled chromatin remodeling
F	0048188	cellular_component	Set1C/COMPASS complex
F	0071339	cellular_component	MLL1 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
E	MET1
F	MET1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
E	SER19
F	SER19

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS35
F	LYS35

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	LYS35
F	LYS35

---