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6DBC

Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABromodomain-containing protein 2polymer11513524.51UniProt (P25440)
Pfam (PF00439)
In PDB
Homo sapiens (Human)O27.1.1,Really interesting new gene 3 protein
2A1,2-ETHANEDIOLnon-polymer62.17Chemie (EDO)
3A1-[(2S,4R)-4-[(2-chlorophenyl)amino]-2-methyl-6-(1H-pyrazol-3-yl)-3,4-dihydroquinolin-1(2H)-yl]ethan-1-onenon-polymer380.91Chemie (G3J)
4waterwater18.0180Chemie (HOH)
Sequence modifications
A: 348 - 455 (UniProt: P25440)
PDBExternal DatabaseDetails
Gly 341-expression tag
Ser 342-expression tag
His 343-expression tag
Met 344-expression tag
Gln 345-expression tag
Asp 346-expression tag
Pro 347-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight13524.5
Non-Polymers*Number of molecules8
Total formula weight815.3
All*Total formula weight14339.8
*Water molecules are not included.

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PDB entries from 2024-07-17

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