6APD
Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Fusion glycoprotein F0,Envelope glycoprotein | polymer | 573 | 63775.9 | 3 | UniProt (C3UPB8) UniProt (M1E1E4) Pfam (PF00523) UniProt (by SIFTS) (P03420) UniProt (by SIFTS) (P10104) | Respiratory syncytial virus | |
| 2 | D, F, H (D, F, H) | AM22 Fab Heavy Chain,IGH@ protein | polymer | 228 | 24123.2 | 3 | UniProt (Q6GMX6) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | E, G, I (E, G, I) | AM22 Fab Light Chain,Uncharacterized protein | polymer | 215 | 23305.0 | 3 | UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) | Homo sapiens | |
| 4 | J, K, N (J, K, N) | Immunoglobulin heavy variable 3-21,Immunoglobulin gamma-1 heavy chain | polymer | 226 | 23881.7 | 3 | UniProt (A0A0B4J1V1) UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 5 | L, M, O (L, M, O) | IGL@ protein | polymer | 218 | 22955.3 | 3 | UniProt (Q6GMX4) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) |
Sequence modifications
A, B, C: 1 - 513 (UniProt: C3UPB8)
A, B, C: 518 - 546 (UniProt: M1E1E4)
D, F, H: 1 - 100 (PDB: 6APD)
D, F, H: 101 - 217 (UniProt: Q6GMX6)
E, G, I: 1 - 106 (PDB: 6APD)
E, G, I: 107 - 214 (UniProt: Q8TCD0)
J, K, N: 1 - 94 (UniProt: A0A0B4J1V1)
J, K, N: 103 - 217 (UniProt: P0DOX5)
L, M, O: 1 - 213 (UniProt: Q6GMX4)
| PDB | External Database | Details |
|---|---|---|
| Glu 66 | Lys 66 | conflict |
| Ile 67 | Asn 67 | engineered mutation |
| Val 76 | Ile 76 | conflict |
| Pro 215 | Ser 215 | engineered mutation |
| Ser 514 | - | linker |
| Ala 515 | - | linker |
| Ile 516 | - | linker |
| Gly 517 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 547 | - | expression tag |
| Glu 548 | - | expression tag |
| Val 549 | - | expression tag |
| Leu 550 | - | expression tag |
| Phe 551 | - | expression tag |
| Gln 552 | - | expression tag |
| Gly 553 | - | expression tag |
| Pro 554 | - | expression tag |
| Gly 555 | - | expression tag |
| His 556 | - | expression tag |
| His 557 | - | expression tag |
| His 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| Ser 564 | - | expression tag |
| Ala 565 | - | expression tag |
| Trp 566 | - | expression tag |
| Ser 567 | - | expression tag |
| His 568 | - | expression tag |
| Pro 569 | - | expression tag |
| Gln 570 | - | expression tag |
| Phe 571 | - | expression tag |
| Glu 572 | - | expression tag |
| Lys 573 | - | expression tag |
D, F, H: 101 - 217 (UniProt: Q6GMX6)
E, G, I: 1 - 106 (PDB: 6APD)
E, G, I: 107 - 214 (UniProt: Q8TCD0)
J, K, N: 1 - 94 (UniProt: A0A0B4J1V1)
| PDB | External Database | Details |
|---|---|---|
| Leu 95 | - | linker |
| Gly 96 | - | linker |
| Tyr 97 | - | linker |
| Cys 98 | - | linker |
| Ser 99 | - | linker |
| Gly 100 | - | linker |
| Gly 100 | - | linker |
| Ser 100 | - | linker |
| Cys 100 | - | linker |
| His 100 | - | linker |
| Phe 100 | - | linker |
| Asp 101 | - | linker |
| Tyr 102 | - | linker |
L, M, O: 1 - 213 (UniProt: Q6GMX4)
| PDB | External Database | Details |
|---|---|---|
| Lys 45 | Arg 66 | conflict |
| Phe 95 | - | insertion |
| Tyr 96 | Val 119 | conflict |
| Val 97 | Met 120 | conflict |
| Thr 100 | Gly 123 | conflict |
| Val 104 | Leu 127 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 474123.1 | |
| All* | Total formula weight | 474123.1 |
