5ZK1
Crystal Structure of the CRTC2(SeMet)-CREB-CRE complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | DNA (5'-D(*CP*TP*TP*GP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*CP*AP*AP*G)-3') | polymer | 20 | 6135.0 | 1 | synthetic construct | ||
| 2 | B (A) | Cyclic AMP-responsive element-binding protein 1 | polymer | 59 | 7133.3 | 1 | UniProt (P16220) Pfam (PF00170) | Homo sapiens (Human) | CREB, cAMP-responsive element-binding protein 1 |
| 3 | C (C) | CREB-regulated transcription coactivator 2 | polymer | 42 | 4967.4 | 1 | UniProt (Q3U182) Pfam (PF12884) | Mus musculus (Mouse) | Transducer of regulated cAMP response element-binding protein 2,Transducer of CREB protein 2 |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 283 - 341 (UniProt: P16220)
| PDB | External Database | Details |
|---|---|---|
| Ser 300 | Cys 300 | engineered mutation |
| Ser 337 | Cys 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 18235.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 18301.1 |
