5YWT

Crystal structure of TREX1 in complex with a duplex DNA with 3' overhang

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Three-prime repair exonuclease 1	polymer	276	29876.9	2	UniProt (Q91XB0)	Mus musculus (Mouse)	3'-5' exonuclease TREX1,DNase III
2	C, D (D, C)	DNA (5'-D(*GP*GP*CP*CP*CP*T)-3')	polymer	19	5763.7	2		Homo sapiens
3	E, H, I, K (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	F, G, J (A, B)	COBALT (II) ION	non-polymer		58.9	3	Chemie (CO)
5	L, M, N, O (A, B, D, C)	water	water		18.0	568	Chemie (HOH)

Sequence modifications

A, B: 1 - 242 (UniProt: Q91XB0)

PDB	External Database	Details
Met -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
Gly -21	-	expression tag
Leu -20	-	expression tag
Val -19	-	expression tag
Pro -18	-	expression tag
Arg -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	71281.2
Non-Polymers*	Number of molecules	7
	Total formula weight	274.0
All*	Total formula weight	71555.2

*Water molecules are not included.