5Y31
Crystal structure of human LGI1-ADAM22 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Disintegrin and metalloproteinase domain-containing protein 22 | polymer | 497 | 54803.2 | 2 | UniProt (Q9P0K1) Pfam (PF01421) Pfam (PF00200) Pfam (PF08516) Pfam (PF07974) In PDB | Homo sapiens (Human) | ADAM 22,Metalloproteinase-disintegrin ADAM22-3,Metalloproteinase-like,disintegrin-like,and cysteine-rich protein 2 |
2 | B, D | Leucine-rich glioma-inactivated protein 1 | polymer | 544 | 62570.8 | 2 | UniProt (O95970) Pfam (PF03736) Pfam (PF13855) In PDB | Homo sapiens (Human) | Epitempin-1 |
3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
4 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) |
Sequence modifications
B, D: 37 - 557 (UniProt: O95970)
PDB | External Database | Details |
---|---|---|
Asp 21 | - | expression tag |
Ala 22 | - | expression tag |
Ala 23 | - | expression tag |
Gln 24 | - | expression tag |
Pro 25 | - | expression tag |
Ala 26 | - | expression tag |
Arg 27 | - | expression tag |
Arg 28 | - | expression tag |
Ala 29 | - | expression tag |
Arg 30 | - | expression tag |
Arg 31 | - | expression tag |
Thr 32 | - | expression tag |
Tyr 33 | - | expression tag |
Glu 34 | - | expression tag |
Ala 35 | - | expression tag |
Tyr 36 | - | expression tag |
Ala 470 | Arg 470 | engineered mutation |
Lys 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
His 562 | - | expression tag |
His 563 | - | expression tag |
His 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 234748.0 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 2532.7 | |
All* | Total formula weight | 237280.7 |