5Y31
Crystal structure of human LGI1-ADAM22 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0007165 | biological_process | signal transduction |
| B | 0007399 | biological_process | nervous system development |
| B | 0007411 | biological_process | axon guidance |
| B | 0030307 | biological_process | positive regulation of cell growth |
| B | 0030425 | cellular_component | dendrite |
| B | 0031175 | biological_process | neuron projection development |
| B | 0043083 | cellular_component | synaptic cleft |
| B | 0043194 | cellular_component | axon initial segment |
| B | 0045202 | cellular_component | synapse |
| B | 0048018 | molecular_function | receptor ligand activity |
| B | 0050806 | biological_process | positive regulation of synaptic transmission |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| D | 0005102 | molecular_function | signaling receptor binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0007165 | biological_process | signal transduction |
| D | 0007399 | biological_process | nervous system development |
| D | 0007411 | biological_process | axon guidance |
| D | 0030307 | biological_process | positive regulation of cell growth |
| D | 0030425 | cellular_component | dendrite |
| D | 0031175 | biological_process | neuron projection development |
| D | 0043083 | cellular_component | synaptic cleft |
| D | 0043194 | cellular_component | axon initial segment |
| D | 0045202 | cellular_component | synapse |
| D | 0048018 | molecular_function | receptor ligand activity |
| D | 0050806 | biological_process | positive regulation of synaptic transmission |
| D | 0098978 | cellular_component | glutamatergic synapse |
| D | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 398 |
| Details | Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 174 |
| Details | Domain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 74 |
| Details | Domain: {"description":"EGF-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19692335","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 100 |
| Details | Domain: {"description":"LRRCT"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"EAR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"EAR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 94 |
| Details | Repeat: {"description":"EAR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 98 |
| Details | Repeat: {"description":"EAR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"EAR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"EAR 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00075","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
