5Y2Z
Crystal structure of human LGI1 EPTP-ADAM22 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... | Disintegrin and metalloproteinase domain-containing protein 22 | polymer | 504 | 55761.3 | 6 | UniProt (Q9P0K1) Pfam (PF01421) Pfam (PF00200) Pfam (PF08516) Pfam (PF07974) In PDB | Homo sapiens (Human) | ADAM 22,Metalloproteinase-disintegrin ADAM22-3,Metalloproteinase-like,disintegrin-like,and cysteine-rich protein 2 |
| 2 | B, D, F, H, J... | Leucine-rich glioma-inactivated protein 1 | polymer | 347 | 40378.5 | 6 | UniProt (O95970) Pfam (PF03736) In PDB | Homo sapiens (Human) | Epitempin-1 |
| 3 | M, O, Q, T | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | N, S | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 5 | P, U, V | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 6 | R | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 7 | C, E, G, I, K... | CALCIUM ION | non-polymer | 40.1 | 24 | Chemie (CA) | |||
| 8 | H, L | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 9 | water | water | 18.0 | 914 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 233 - 729 (UniProt: Q9P0K1)
B, D, F, H, J, L: 224 - 557 (UniProt: O95970)
| PDB | External Database | Details |
|---|---|---|
| Lys 730 | - | expression tag |
| His 731 | - | expression tag |
| His 732 | - | expression tag |
| His 733 | - | expression tag |
| His 734 | - | expression tag |
| His 735 | - | expression tag |
| His 736 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 218 | - | expression tag |
| Ala 219 | - | expression tag |
| Ala 220 | - | expression tag |
| Gln 221 | - | expression tag |
| Pro 222 | - | expression tag |
| Ala 223 | - | expression tag |
| Lys 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 576838.8 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5241.9 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 1404.3 | |
| All* | Total formula weight | 583485.1 |
