5X6V
Crystal structure of human heteroheptameric complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ragulator complex protein LAMTOR3 | polymer | 127 | 13868.9 | 1 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 2 | B (B) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 3 | C (C) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 1 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 4 | D (D) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 5 | E (E) | Ragulator complex protein LAMTOR1 | polymer | 123 | 13405.1 | 1 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 6 | F (F) | Ras-related GTP-binding protein A | polymer | 135 | 15661.1 | 1 | UniProt (Q7L523) | Homo sapiens (Human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 7 | G (G) | Ras-related GTP-binding protein C | polymer | 139 | 15764.2 | 1 | UniProt (Q99K70) | Mus musculus (Mouse) | RagC,GTPase-interacting protein 2,TIB929 |
| 8 | H (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 9 | I (G) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 10 | J, K, L, M, N... (A, B, C, D, E...) | water | water | 18.0 | 348 | Chemie (HOH) |
Sequence modifications
A: 2 - 124 (UniProt: Q9UHA4)
E: 42 - 161 (UniProt: Q6IAA8)
F: 183 - 313 (UniProt: Q7L523)
G: 238 - 375 (UniProt: Q99K70)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| Ala 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Asp 98 | Ser 98 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 179 | - | expression tag |
| Ala 180 | - | expression tag |
| Asp 181 | - | expression tag |
| Leu 182 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 237 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 92592.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 82.0 | |
| All* | Total formula weight | 92674.9 |
