5X6V

Crystal structure of human heteroheptameric complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ragulator complex protein LAMTOR3	polymer	127	13868.9	1	UniProt (Q9UHA4) Pfam (PF08923) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
2	B	Ragulator complex protein LAMTOR2	polymer	125	13517.5	1	UniProt (Q9Y2Q5) Pfam (PF03259) In PDB	Homo sapiens (Human)	Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
3	C	Ragulator complex protein LAMTOR5	polymer	91	9622.9	1	UniProt (O43504) Pfam (PF16672) In PDB	Homo sapiens (Human)	Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
4	D	Ragulator complex protein LAMTOR4	polymer	99	10753.2	1	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
5	E	Ragulator complex protein LAMTOR1	polymer	123	13405.1	1	UniProt (Q6IAA8) Pfam (PF15454) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
6	F	Ras-related GTP-binding protein A	polymer	135	15661.1	1	UniProt (Q7L523) In PDB	Homo sapiens (Human)	RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1
7	G	Ras-related GTP-binding protein C	polymer	139	15764.2	1	UniProt (Q99K70) In PDB	Mus musculus (Mouse)	RagC,GTPase-interacting protein 2,TIB929
8	C	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
9	G	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
10		water	water		18.0	348	Chemie (HOH)

Sequence modifications

A: 2 - 124 (UniProt: Q9UHA4)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag

E: 42 - 161 (UniProt: Q6IAA8)

PDB	External Database	Details
Gly 39	-	expression tag
Ala 40	-	expression tag
Ala 41	-	expression tag
Asp 98	Ser 98	engineered mutation

F: 183 - 313 (UniProt: Q7L523)

PDB	External Database	Details
Met 179	-	expression tag
Ala 180	-	expression tag
Asp 181	-	expression tag
Leu 182	-	expression tag

G: 238 - 375 (UniProt: Q99K70)

PDB	External Database	Details
Met 237	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	92592.8
Non-Polymers*	Number of molecules	2
	Total formula weight	82.0
All*	Total formula weight	92674.9

*Water molecules are not included.