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5X6V

Crystal structure of human heteroheptameric complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0008104biological_processprotein localization
A0010008cellular_componentendosome membrane
A0016020cellular_componentmembrane
A0019209molecular_functionkinase activator activity
A0031902cellular_componentlate endosome membrane
A0032006biological_processregulation of TOR signaling
A0032008biological_processpositive regulation of TOR signaling
A0035579cellular_componentspecific granule membrane
A0038202biological_processTORC1 signaling
A0043410biological_processpositive regulation of MAPK cascade
A0060090molecular_functionmolecular adaptor activity
A0070062cellular_componentextracellular exosome
A0070821cellular_componenttertiary granule membrane
A0071230biological_processcellular response to amino acid stimulus
A0071986cellular_componentRagulator complex
A1902414biological_processprotein localization to cell junction
A1904263biological_processpositive regulation of TORC1 signaling
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0001558biological_processregulation of cell growth
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0008104biological_processprotein localization
B0010008cellular_componentendosome membrane
B0010761biological_processfibroblast migration
B0016020cellular_componentmembrane
B0031902cellular_componentlate endosome membrane
B0032008biological_processpositive regulation of TOR signaling
B0035579cellular_componentspecific granule membrane
B0038202biological_processTORC1 signaling
B0043410biological_processpositive regulation of MAPK cascade
B0060090molecular_functionmolecular adaptor activity
B0070821cellular_componenttertiary granule membrane
B0071230biological_processcellular response to amino acid stimulus
B0071986cellular_componentRagulator complex
B0150116biological_processregulation of cell-substrate junction organization
B1902414biological_processprotein localization to cell junction
B1904263biological_processpositive regulation of TORC1 signaling
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0008361biological_processregulation of cell size
C0009615biological_processresponse to virus
C0010628biological_processpositive regulation of gene expression
C0019079biological_processviral genome replication
C0031902cellular_componentlate endosome membrane
C0032008biological_processpositive regulation of TOR signaling
C0032757biological_processpositive regulation of interleukin-8 production
C0032991cellular_componentprotein-containing complex
C0038202biological_processTORC1 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0060090molecular_functionmolecular adaptor activity
C0061462biological_processprotein localization to lysosome
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C1900182biological_processpositive regulation of protein localization to nucleus
C1904263biological_processpositive regulation of TORC1 signaling
C1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0008361biological_processregulation of cell size
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0038202biological_processTORC1 signaling
D0043231cellular_componentintracellular membrane-bounded organelle
D0060090molecular_functionmolecular adaptor activity
D0061462biological_processprotein localization to lysosome
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0001919biological_processregulation of receptor recycling
E0007040biological_processlysosome organization
E0016197biological_processendosomal transport
E0031902cellular_componentlate endosome membrane
E0032008biological_processpositive regulation of TOR signaling
E0042632biological_processcholesterol homeostasis
E0043410biological_processpositive regulation of MAPK cascade
E0045121cellular_componentmembrane raft
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
F0005525molecular_functionGTP binding
G0005525molecular_functionGTP binding
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue NA C 101
ChainResidue
CMET13
CASN15
CILE18

site_idAC2
Number of Residues5
Detailsbinding site for residue ACT G 401
ChainResidue
CTHR4
CHIS8
GTYR268
GVAL276
GHOH502

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER309
ESER56
EASP98
ESER141

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25936802
ChainResidueDetails
FLYS220
FLYS230
FLYS244

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22
ChainResidueDetails
DSER67
ELYS103
ELYS104

219140

PDB entries from 2024-05-01

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