5WYN

HtrA2 Pathogenic Mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine protease HTRA2, mitochondrial	polymer	332	36017.0	1	UniProt (O43464) Pfam (PF13365) Pfam (PF17820) In PDB	Homo sapiens (Human)	High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI
2	A	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
3	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
4		water	water		18.0	188	Chemie (HOH)

Sequence modifications

A: 1 - 325 (UniProt: O43464)

PDB	External Database	Details
Met 0	-	expression tag
Cys 143	Ser 276	engineered mutation
Trp 295	Tyr 428	engineered mutation
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36017.0
Non-Polymers*	Number of molecules	7
	Total formula weight	408.0
All*	Total formula weight	36424.9

*Water molecules are not included.