5WYN
HtrA2 Pathogenic Mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine protease HTRA2, mitochondrial | polymer | 332 | 36017.0 | 1 | UniProt (O43464) Pfam (PF13365) Pfam (PF17820) | Homo sapiens (Human) | High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI |
| 2 | B, C, D, E, F... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 3 | H (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | I (A) | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A: 1 - 325 (UniProt: O43464)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Cys 143 | Ser 276 | engineered mutation |
| Trp 295 | Tyr 428 | engineered mutation |
| His 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36017.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 408.0 | |
| All* | Total formula weight | 36424.9 |
