5WYN

HtrA2 Pathogenic Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	GLU160
A	HOH661

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 403

Chain	Residue
A	VAL263

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site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 404

Chain	Residue
A	ILE264
A	LEU265

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 405

Chain	Residue
A	LEU259
A	HIS261

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site_id	AC5
Number of Residues	4
Details	binding site for residue CL A 406

Chain	Residue
A	GLY230
A	TRP295
A	TYR228
A	ILE229

---

site_id	AC6
Number of Residues	10
Details	binding site for residue MES A 407

Chain	Residue
A	SER12
A	GLN13
A	TYR14
A	ASN15
A	ASP19
A	HIS37
A	PRO38
A	PHE39
A	LEU40
A	ARG119

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	81
Details	Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11967569","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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