5VK2
Structural basis for antibody-mediated neutralization of Lassa virus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, B, C) | Pre-glycoprotein polyprotein GP complex | polymer | 259 | 29098.4 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus (LASV) | |
| 2 | B, D, F (a, b, c) | Pre-glycoprotein polyprotein GP complex | polymer | 164 | 19116.7 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) | |
| 3 | G, I, K (D, F, H) | Fab 37.7H heavy chain | polymer | 229 | 24342.3 | 3 | Homo sapiens (Human) | ||
| 4 | H, J, L (E, G, L) | Fab 37.7H light chain | polymer | 217 | 23103.5 | 3 | Homo sapiens (Human) | ||
| 5 | CA, M, Y (Z, I, V) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, BA, EA, N, O... (X, Y, e, J, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 11 | In PDB GlyTouCan (G42666HT) | |||
| 7 | DA, Q, W (d, N, T) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 8 | FA, S, X (f, P, U) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 9 | GA, HA, IA, JA, KA... (A, a, B, b, C...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 259 (UniProt: P08669)
a, b, c: 260 - 423 (UniProt: P08669)
| PDB | External Database | Details |
|---|---|---|
| Cys 207 | Arg 207 | engineered mutation |
| Arg 258 | Leu 258 | engineered mutation |
| Arg 259 | Leu 259 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Thr 332 | Met 332 | engineered mutation |
| Cys 360 | Gly 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 286983.0 | |
| Branched | Number of molecules | 20 |
| Total formula weight | 10385.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2433.3 | |
| All* | Total formula weight | 299802.0 |
