5UPK
CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PAK 4 | polymer | 48 | 5653.3 | 1 | UniProt (O96013) Pfam (PF00786) | Homo sapiens (Human) | p21-activated kinase 4,PAK-4 |
| 2 | B (B) | Serine/threonine-protein kinase PAK 4 | polymer | 346 | 39123.1 | 1 | UniProt (O96013) Pfam (PF00069) | Homo sapiens (Human) | p21-activated kinase 4,PAK-4 |
| 3 | C (C) | Cell division control protein 42 homolog | polymer | 185 | 20729.8 | 1 | UniProt (P60953) Pfam (PF00071) | Homo sapiens (Human) | G25K GTP-binding protein |
| 4 | D (B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | E (C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 6 | F (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | G, H (B, C) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 1 - 45 (UniProt: O96013)
B: 274 - 591 (UniProt: O96013)
C: 1 - 177 (UniProt: P60953)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 246 | - | initiating methionine |
| Gly 247 | - | expression tag |
| Ser 248 | - | expression tag |
| Ser 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
| Ser 256 | - | expression tag |
| Ser 257 | - | expression tag |
| Gly 258 | - | expression tag |
| Leu 259 | - | expression tag |
| Val 260 | - | expression tag |
| Pro 261 | - | expression tag |
| Arg 262 | - | expression tag |
| Gly 263 | - | expression tag |
| Ser 264 | - | expression tag |
| His 265 | - | expression tag |
| Met 266 | - | expression tag |
| Glu 267 | - | expression tag |
| Asn 268 | - | expression tag |
| Leu 269 | - | expression tag |
| Tyr 270 | - | expression tag |
| Phe 271 | - | expression tag |
| Gln 272 | - | expression tag |
| Gly 273 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 61 | Gln 61 | engineered mutation |
| Arg 163 | Lys 163 | conflict |
| Leu 178 | - | expression tag |
| Glu 179 | - | expression tag |
| His 180 | - | expression tag |
| His 181 | - | expression tag |
| His 182 | - | expression tag |
| His 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 65506.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1052.7 | |
| All* | Total formula weight | 66558.9 |
