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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5UPK

CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42

Functional Information from GO Data
ChainGOidnamespacecontents
A0004674molecular_functionprotein serine/threonine kinase activity
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000322cellular_componentstorage vacuole
C0003015biological_processheart process
C0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007163biological_processestablishment or maintenance of cell polarity
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017119cellular_componentGolgi transport complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030010biological_processestablishment of cell polarity
C0030036biological_processactin cytoskeleton organization
C0030154biological_processcell differentiation
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031252cellular_componentcell leading edge
C0031256cellular_componentleading edge membrane
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0035050biological_processembryonic heart tube development
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0044788biological_processhost-mediated perturbation of viral process
C0045177cellular_componentapical part of cell
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045335cellular_componentphagocytic vesicle
C0048549biological_processpositive regulation of pinocytosis
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051683biological_processestablishment of Golgi localization
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C0086100biological_processendothelin receptor signaling pathway
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099175biological_processregulation of postsynapse organization
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue ANP B 600
ChainResidue
BGLU329
BHOH722
BGLY330
BVAL335
BLYS350
BMET395
BGLU396
BPHE397
BLEU398
BLEU447
site_idAC2
Number of Residues19
Detailsbinding site for residue GNP C 200
ChainResidue
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CGLU31
CTYR32
CTHR35
CGLY60
CLEU61
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CMG201
CHOH301
site_idAC3
Number of Residues4
Detailsbinding site for residue MG C 201
ChainResidue
CTHR17
CVAL33
CTHR35
CGNP200
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK
ChainResidueDetails
BILE327-LYS351
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues13
DetailsDomain: {"description":"CRIB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00057","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of the human p21-activated kinase 4.","authors":["Eswaran J.","Debreczeni J.E.","Bunkoczi G.","Filippakopoulos P.","Das S.","Fedorov O.","Sundstrom M.","Arrowsmith C.","Edwards A.","von Delft F.","Knapp S."]}},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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