Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5UPK

CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42

Functional Information from GO Data
ChainGOidnamespacecontents
A0004674molecular_functionprotein serine/threonine kinase activity
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0000139cellular_componentGolgi membrane
C0000322cellular_componentstorage vacuole
C0002040biological_processsprouting angiogenesis
C0003015biological_processheart process
C0003161biological_processcardiac conduction system development
C0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007088biological_processregulation of mitotic nuclear division
C0007097biological_processnuclear migration
C0007163biological_processestablishment or maintenance of cell polarity
C0007229biological_processintegrin-mediated signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0008104biological_processprotein localization
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017119cellular_componentGolgi transport complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030036biological_processactin cytoskeleton organization
C0030141cellular_componentsecretory granule
C0030154biological_processcell differentiation
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031252cellular_componentcell leading edge
C0031256cellular_componentleading edge membrane
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032488biological_processCdc42 protein signal transduction
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0034332biological_processadherens junction organization
C0035050biological_processembryonic heart tube development
C0035088biological_processestablishment or maintenance of apical/basal cell polarity
C0036336biological_processdendritic cell migration
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043226cellular_componentorganelle
C0043410biological_processpositive regulation of MAPK cascade
C0043525biological_processpositive regulation of neuron apoptotic process
C0044788biological_processmodulation by host of viral process
C0045177cellular_componentapical part of cell
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045335cellular_componentphagocytic vesicle
C0045740biological_processpositive regulation of DNA replication
C0046330biological_processpositive regulation of JNK cascade
C0046847biological_processfilopodium assembly
C0048549biological_processpositive regulation of pinocytosis
C0048664biological_processneuron fate determination
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051647biological_processnucleus localization
C0051649biological_processestablishment of localization in cell
C0051683biological_processestablishment of Golgi localization
C0051835biological_processpositive regulation of synapse structural plasticity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060047biological_processheart contraction
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060661biological_processsubmandibular salivary gland formation
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071346biological_processcellular response to type II interferon
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C0086101biological_processendothelin receptor signaling pathway involved in heart process
C0090135biological_processactin filament branching
C0090316biological_processpositive regulation of intracellular protein transport
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0099175biological_processregulation of postsynapse organization
C0099563biological_processmodification of synaptic structure
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue ANP B 600
ChainResidue
BGLU329
BHOH722
BGLY330
BVAL335
BLYS350
BMET395
BGLU396
BPHE397
BLEU398
BLEU447

site_idAC2
Number of Residues19
Detailsbinding site for residue GNP C 200
ChainResidue
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CGLU31
CTYR32
CTHR35
CGLY60
CLEU61
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CMG201
CHOH301

site_idAC3
Number of Residues4
Detailsbinding site for residue MG C 201
ChainResidue
CTHR17
CVAL33
CTHR35
CGNP200

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK
ChainResidueDetails
BILE327-LYS351

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING:
ChainResidueDetails
CGLY10
CTHR115

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CASP57
BLYS350

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
CTYR32
BASP458

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
BTHR332
BALA423
BSER291

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
CTYR64

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BASP372

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976
ChainResidueDetails
BHIS432

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|Ref.32, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSEP474

220113

PDB entries from 2024-05-22

PDB statisticsPDBj update infoContact PDBjnumon