5TZU
Crystal structure of human CD47 ECD bound to Fab of B6H12.2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L | Light Chain of Fab B6H12.2 | polymer | 214 | 23373.9 | 1 | Homo sapiens | ||
2 | H | Heavy Chain of Fab B6H12.2 | polymer | 227 | 24196.1 | 1 | Homo sapiens | ||
3 | C | Leukocyte surface antigen CD47 | polymer | 129 | 14764.5 | 1 | UniProt (Q08722) Pfam (PF08204) In PDB | Homo sapiens (Human) | Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6 |
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | B | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
6 | D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
7 | L, H | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
8 | H, C | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
9 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
10 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
11 | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence modifications
C: 1 - 123 (UniProt: Q08722)
PDB | External Database | Details |
---|---|---|
Gly 15 | Cys 33 | engineered mutation |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
His 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 62334.5 | |
Branched | Number of molecules | 3 |
Total formula weight | 1921.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 903.8 | |
All* | Total formula weight | 65160.1 |