5TIH
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cysteine-rich protective antigen | polymer | 335 | 39485.4 | 1 | UniProt (Q8IFM8) Pfam (PF18638) | Plasmodium falciparum | |
| 2 | B (H) | CyRPA antibody Fab Heavy Chain | polymer | 215 | 23343.3 | 1 | Mus musculus | ||
| 3 | C (L) | CyRPA antibody Fab Light Chain | polymer | 212 | 23532.8 | 1 | Mus musculus | ||
| 4 | D, E, F (A, L) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | G, H, I (A, H, L) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 1 - 333 (UniProt: Q8IFM8)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Ala 118 | Ser 147 | conflict |
| Ala 295 | Thr 324 | conflict |
| Ala 311 | Thr 340 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 86361.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 177.1 | |
| All* | Total formula weight | 86538.6 |
