5SXG
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DNA dC->dU-editing enzyme APOBEC-3B | polymer | 185 | 21821.7 | 2 | UniProt (Q9UH17) Pfam (PF05240) In PDB | Homo sapiens (Human) | A3B,Phorbolin-1-related protein,Phorbolin-2/3 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | 1,3-PROPANDIOL | non-polymer | 76.1 | 6 | Chemie (PDO) | |||
| 4 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 5 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 378 (UniProt: Q9UH17)
| PDB | External Database | Details |
|---|---|---|
| Ser 186 | - | expression tag |
| Glu 187 | - | expression tag |
| Ile 188 | - | expression tag |
| Leu 189 | - | expression tag |
| Arg 190 | - | expression tag |
| Ser 200 | Phe 200 | engineered mutation |
| Ser 228 | Trp 228 | engineered mutation |
| Lys 230 | Leu 230 | engineered mutation |
| - | Ala 242 | deletion |
| - | Lys 243 | deletion |
| - | Asn 244 | deletion |
| - | Leu 245 | deletion |
| - | Leu 246 | deletion |
| - | Cys 247 | deletion |
| - | Gly 248 | deletion |
| - | Phe 249 | deletion |
| Ser 250 | Tyr 250 | engineered mutation |
| Lys 308 | Phe 308 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43643.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 656.5 | |
| All* | Total formula weight | 44299.8 |
