5NI6
Crystal structure of human LTA4H mutant D375N in complex with LTA4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leukotriene A-4 hydrolase | polymer | 617 | 70191.9 | 1 | UniProt (P09960) Pfam (PF17900) Pfam (PF01433) Pfam (PF09127) | Homo sapiens (Human) | LTA-4 hydrolase,Leukotriene A(4) hydrolase |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | YTTERBIUM (III) ION | non-polymer | 173.0 | 2 | Chemie (YB) | |||
| 4 | E, G (A) | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
| 5 | F (A) | 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | non-polymer | 318.4 | 1 | Chemie (DJ3) | |||
| 6 | H (A) | water | water | 18.0 | 825 | Chemie (HOH) |
Sequence modifications
A: 1 - 610 (UniProt: P09960)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Asn 375 | Asp 376 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 70191.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 850.0 | |
| All* | Total formula weight | 71041.9 |
